INT278332

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) lysosome (Ctsb) cytoplasm (Ctsb)
Ctsb (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 26.64 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 111 100.00 Very High Very High Very High
Cancer 144 99.70 Very High Very High Very High
Metastasis 9 86.40 High High
Adhesions 34 70.00 Quite High
Glioblastoma 11 65.60 Quite High
Apoptosis 31 45.80 Quite Low
Anaplastic Astrocytoma 2 41.48 Quite Low
Brain Tumor 1 38.28 Quite Low
Hyperplasia 6 29.60 Quite Low
Stress 1 25.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of shRNA constructs on MMP-9, uPAR, and cathepsin B
Regulation (Effect) of cathepsin B
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.31 Pain Relevance 0
production is by modulating intracellular calcium concentration or cathepsin B activation.
Regulation (modulating) of cathepsin B
2) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Immunohistochemical analysis of the tumor sections from control mice for cathepsin B and uPAR showed increased expression levels localized to the tumor region while the pCU-treated tumor sections revealed very little or no expression of the cathepsin B and uPAR.
Regulation (control) of cathepsin B associated with cancer
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.66 Pain Relevance 0
Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.
Regulation (targets) of Cathepsin B associated with glioma
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.87 Pain Relevance 0
To gain insight into the molecular roles of cathepsin B and uPAR, we knocked down the expression of these molecules using shRNA in SNB19 and U251 glioma cells and then analyzed the effects on cell proliferation and cell cycle.
Regulation (roles) of cathepsin B associated with glioma
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.22 Pain Relevance 0

General Comments

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