INT278340

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.92
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Syk) cytoplasm (Syk)
Anatomy Link Frequency
erythrocyte 1
B cell 1
Syk (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 192 99.40 Very High Very High Very High
Inflammation 177 99.08 Very High Very High Very High
chemokine 24 95.52 Very High Very High Very High
cytokine 105 94.92 High High
Inflammatory mediators 12 90.92 High High
rheumatoid arthritis 195 80.40 Quite High
Central nervous system 3 45.56 Quite Low
Inflammatory response 33 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Plasmodium Infection 102 100.00 Very High Very High Very High
Arthritis 186 99.40 Very High Very High Very High
Synovitis 3 97.72 Very High Very High Very High
Apoptosis 147 95.72 Very High Very High Very High
Rupture 18 95.64 Very High Very High Very High
INFLAMMATION 135 90.92 High High
Disease 45 88.60 High High
Death 15 88.48 High High
Targeted Disruption 15 82.76 Quite High
Rheumatoid Arthritis 195 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the widely expressed Spleen Tyrosine Kinase (Syk) was shown to be required for cathepsin B release into the cytosol in a model of B cell receptor-mediated apoptosis [25].
Gene_expression (expressed) of Syk in B cell associated with apoptosis
1) Confidence 0.51 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.28 Pain Relevance 0
Finally, Syk was found to control the activation of cathepsin B and Hz-induced IL-1?
Gene_expression (found) of Syk
2) Confidence 0.44 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Altogether, these results reveal that Lyn/Syk activation following Hz exposure initiates the PI3K and ERK signaling pathways and these pathways appear to regulate the production of mature IL-1?.
Gene_expression (exposure) of Syk
3) Confidence 0.44 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
We then carried out anti-Syk immunoprecipitation, followed by anti phospho-tyrosine analysis and found that Syk was phosphorylated in response to Hz, but not MSU stimulation (Fig. 5B).
Gene_expression (immunoprecipitation) of Syk
4) Confidence 0.44 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.24 Pain Relevance 0
Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

The intraerythrocytic parasite Plasmodium—the causative agent of malaria—produces an inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is released into the circulation during erythrocyte lysis.

Gene_expression (produces) of Syk in erythrocyte associated with plasmodium infection
5) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Title Doc Link PMC2722371 Disease Relevance 0.48 Pain Relevance 0.09
The reduced expression of SyK in the R788-treated mice correlated with an amelioration of clinical arthritis, a reduction in proinflammatory chemokines and cytokines, including the CXCR2 ligand KC-GRO-?
Gene_expression (expression) of SyK associated with chemokine, cytokine and arthritis
6) Confidence 0.36 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.84 Pain Relevance 0.48
production though the involvement of the Src kinase Lyn and the tyrosine kinase Syk.
Gene_expression (production) of kinase Syk
7) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 1.08 Pain Relevance 0.26
The discovery of promising specific targets for intervention in the inflammatory arthritis process have included, S1P, IL-7R, Syk, Raf/MEK/ERK 1/2, MK5/PRAK, miRNA, PI3K/PTEN/Akt, NF-?
Gene_expression (/) of Syk associated with inflammation and arthritis
8) Confidence 0.32 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.00 Pain Relevance 0.63
The discovery of promising specific targets for intervention in the inflammatory arthritis process have included, S1P, IL-7R, Syk, Raf/MEK/ERK 1/2, MK5/PRAK, miRNA, PI3K/PTEN/Akt, NF-?
Gene_expression (/) of Syk associated with inflammation and arthritis
9) Confidence 0.32 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.00 Pain Relevance 0.63

General Comments

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