INT278341

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.47
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Hps5) cytoplasm (Hps5)
Anatomy Link Frequency
THP-1 1
Hps5 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 57 89.84 High High
Inflammatory response 28 78.08 Quite High
cytokine 70 65.16 Quite High
Inflammation 56 64.76 Quite High
chemokine 21 63.92 Quite High
postherpetic neuralgia 78 62.28 Quite High
Inflammatory mediators 14 34.88 Quite Low
Lasting pain 9 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Zoster 456 100.00 Very High Very High Very High
Recurrence 3 100.00 Very High Very High Very High
Stroke 3 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 99.40 Very High Very High Very High
Disease 108 98.58 Very High Very High Very High
Infection 84 97.44 Very High Very High Very High
Cytomegalovirus Infection 3 90.72 High High
Salmonella Infection 7 88.24 High High
Pain 57 87.88 High High
Influenza Virus Infection 42 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, Syk was found to control the activation of cathepsin B and Hz-induced IL-1?
Positive_regulation (activation) of Hz-induced
1) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
We showed that specific inhibition of Syk blocked the Hz-induced cathepsin B activation.
Positive_regulation (activation) of Hz-induced
2) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
We therefore attempted to isolate which pathways might be required for Hz-induced IL-1?
Positive_regulation (required) of Hz-induced
3) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Other potential receptors that could mediate Hz-triggered signaling are the Toll-like receptors (TLR).
Positive_regulation (mediate) of Hz
4) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
We found that Hz- and MSU-induced caspase-1 activation and IL-1?
Positive_regulation (activation) of Hz
5) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.17 Pain Relevance 0.04
Furthermore, Hz-induced Syk activation is not affected by the absence of the MyD88 adaptor protein (Fig.
Positive_regulation (activation) of Hz-induced
6) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
secretion by PMA-differentiated human monocytic cell line (THP-1) stimulated with increasing concentrations of Hz or MSU.
Positive_regulation (increasing) of Hz in THP-1
7) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.06 Pain Relevance 0.10
Moreover, the HZ vaccine could be relevant because of the predicted temporary increase in the incidence of HZ after introducing childhood varicella vaccination [21].
Positive_regulation (increase) of HZ associated with herpes zoster
8) Confidence 0.04 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2928772 Disease Relevance 1.58 Pain Relevance 0.27
In HIV-infected persons the risk of HZ and its recurrence is increased (12-17 fold) [1].
Positive_regulation (increased) of HZ associated with herpes zoster, acquired immune deficiency syndrome or hiv infection and recurrence
9) Confidence 0.04 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2928772 Disease Relevance 1.82 Pain Relevance 0.06
The indirect disease burden estimations might increase in future, if the recently reported increased risk of stroke after HZ is being confirmed in future research [33].
Positive_regulation (increased) of HZ associated with stroke, herpes zoster and disease
10) Confidence 0.03 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2928772 Disease Relevance 1.84 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox