INT278346

Context Info Confidence 0.33 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

kinase activity (Syk) cytoplasm (Syk)

Syk (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 10 5.00 Inflammation 8 5.00 Inflammatory response 4 5.00 chemokine 3 5.00 Inflammatory mediators 2 5.00 imagery 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Plasmodium Infection 17 5.00 INFLAMMATION 14 5.00 Infection 9 5.00 Fever 6 5.00 Disease 6 5.00 Parasitemia 4 5.00 Rupture 3 5.00 Crystal Associated Disease 2 5.00 Targeted Disruption 2 5.00 Apoptosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To test whether the PI3K pathway is required for propagation of the Syk signaling pathway following Hz exposure, the PI3K inhibitor wortmannin was used prior to Hz stimulation.

Spec (whether) Positive_regulation (required) of Spec (whether) Negative_regulation (propagation) of Syk

1) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.