INT27835

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Context Info
Confidence 0.44
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.27
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 10
sensory nerves 2
heart 2
kidney 2
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 2 100.00 Very High Very High Very High
guanethidine 3 99.84 Very High Very High Very High
fluoxetine 9 99.82 Very High Very High Very High
bradykinin 2 98.48 Very High Very High Very High
anesthesia 5 96.52 Very High Very High Very High
halothane 2 96.24 Very High Very High Very High
substance P 6 94.04 High High
Serotonin 3 92.56 High High
qutenza 10 91.92 High High
antagonist 8 85.68 High High
Disease Link Frequency Relevance Heat
Natriuresis 3 100.00 Very High Very High Very High
INFLAMMATION 1 100.00 Very High Very High Very High
Obesity 7 98.48 Very High Very High Very High
Renal Artery Obstruction 2 98.36 Very High Very High Very High
Pressure And Volume Under Development 31 95.12 Very High Very High Very High
Increased Venous Pressure Under Development 2 89.76 High High
Weight Gain 1 81.80 Quite High
Body Weight 1 81.60 Quite High
Muscle Hypotonia 1 79.72 Quite High
Diabetes Mellitus 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We compared the effect of two commonly prescribed nonsteroidal anti-inflammatory drugs, ibuprofen and sulindac, and placebo on intravenous furosemide-induced natriuresis and renin stimulation in 11 healthy male volunteers, consuming a 100 mEq sodium, 80 mEq potassium diet.
Regulation (effect) of Positive_regulation (stimulation) of renin associated with natriuresis, inflammation and cinod
1) Confidence 0.44 Published 1985 Journal Nephron Section Abstract Doc Link 3903529 Disease Relevance 0.34 Pain Relevance 0.10
In the present study, we tested the effects of bilateral electrolytic lesions of the ventromedial nuclei on the increase in plasma renin activity produced in sham-operated rats by immobilization, head-up tilt under inactin anesthesia, and a low-sodium diet.
Regulation (effects) of Positive_regulation (increase) of plasma renin in plasma associated with anesthesia
2) Confidence 0.39 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3041306 Disease Relevance 0 Pain Relevance 0.10
Several artifacts were shown to contribute to myocardial renin-like enzymatic activity levels after BNX, including initial plasma renin stimulation during BNX surgery, assay pH, and cardiac cathepsin D activity.
Regulation (contribute) of Positive_regulation (stimulation) of plasma renin in plasma
3) Confidence 0.39 Published 2001 Journal Basic Res. Cardiol. Section Abstract Doc Link 11770086 Disease Relevance 0.07 Pain Relevance 0
In contrast, fluoxetine did not alter the (+/-)-DOI-induced increases in plasma ACTH, corticosterone, or renin.
Regulation (alter) of Positive_regulation (increases) of renin in plasma associated with fluoxetine
4) Confidence 0.33 Published 2005 Journal Synapse Section Abstract Doc Link 16088947 Disease Relevance 0.16 Pain Relevance 0.79
This anaesthesia-induced increase in plasma renin activity was not altered by guanethidine pretreatment.
Neg (not) Regulation (altered) of Positive_regulation (increase) of renin in plasma associated with guanethidine
5) Confidence 0.27 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2699355 Disease Relevance 0.08 Pain Relevance 0.68
The infusion of endothelin into the renal artery of anesthetized rats at 1 ng/kg per min, a dose with no influence on renal function, had no effect on the basal levels of plasma renin activity (PRA) and renin secretory rate (RSR), but significantly inhibited the isoproterenol-induced increases in PRA and RSR.
Neg (no) Regulation (effect) of Neg (no) Positive_regulation (effect) of renin in plasma
6) Confidence 0.27 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2680527 Disease Relevance 0 Pain Relevance 0
We conclude that the mechanisms involved in the decreased responsiveness of the renal sensory nerves in STZ rats involve activation of the renin angiotensin system in STZ but not in obese ZDF rats.
Regulation (involve) of Positive_regulation (activation) of renin in sensory nerves associated with obesity
7) Confidence 0.26 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18199587 Disease Relevance 0.73 Pain Relevance 0.20
Captopril effected a marked elevation of plasma renin activity by its blocking action on the angiotensin II-mediated negative feedback of renin release without markedly altering systemic blood pressure and heart rate.
Regulation (effected) of Positive_regulation (elevation) of renin in heart
8) Confidence 0.24 Published 1981 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6275810 Disease Relevance 0 Pain Relevance 0.05
Increased renin levels and increased ACTH release seemed to be responsible for increased aldosterone secretion, intra-operatively.
Regulation (responsible) of Positive_regulation (Increased) of renin
9) Confidence 0.02 Published 1986 Journal Eur J Anaesthesiol Section Abstract Doc Link 3021443 Disease Relevance 0 Pain Relevance 0.32
It has been shown to be less dependent on the activation of the renin-angiotensin system (RAS) than the two-kidney, one-clip model.
Regulation (dependent) of Positive_regulation (activation) of renin-angiotensin system in kidney
10) Confidence 0.01 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024648 Disease Relevance 0.90 Pain Relevance 0.14

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