INT278350

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.80
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nlrp3)
Anatomy Link Frequency
immune system 1
Nlrp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 82 96.96 Very High Very High Very High
Inflammation 81 96.24 Very High Very High Very High
Antinociceptive 2 71.60 Quite High
antagonist 3 67.44 Quite High
cytokine 24 63.52 Quite High
Neuropathic pain 2 61.64 Quite High
Inflammatory mediators 3 59.44 Quite High
Peripheral nerve injury 1 53.40 Quite High
reflex sympathetic dystrophy 3 38.96 Quite Low
Spinal cord 1 27.20 Quite Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 119 98.40 Very High Very High Very High
Infection 9 98.18 Very High Very High Very High
Plasmodium Infection 17 97.52 Very High Very High Very High
Disease 103 96.96 Very High Very High Very High
INFLAMMATION 86 96.24 Very High Very High Very High
Rupture 3 69.28 Quite High
Targeted Disruption 4 67.04 Quite High
Neuropathic Pain 2 61.64 Quite High
Fever 20 57.20 Quite High
Nervous System Injury 1 53.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that two of the key regulators of the inflammasomes, NLRP3 and MEFV, do not seem to contribute to UC susceptibility.
Regulation (regulators) of NLRP3 associated with inflammatory bowel disease
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.33 Pain Relevance 0.43
However, one can predict the involvement of the NALP3 inflammasome.
Regulation (involvement) of NALP3
2) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.68 Pain Relevance 0.43
These findings not only identify one way by which the immune system is alerted to malarial infection but also are one of the first to suggest a role for tyrosine kinase signaling pathways in regulation of the NLRP3 inflammasome.


Regulation (regulation) of NLRP3 in immune system associated with infection
3) Confidence 0.23 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2722371 Disease Relevance 0.79 Pain Relevance 0.10

General Comments

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