INT278363

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.30
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Syk) cytoplasm (Syk)
Syk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 40 85.36 High High
cytokine 50 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 70 85.36 High High
Disease 30 84.32 Quite High
Plasmodium Infection 85 75.60 Quite High
Parasitemia 20 56.24 Quite High
Stress 5 47.28 Quite Low
Infection 45 5.00 Very Low Very Low Very Low
Fever 30 5.00 Very Low Very Low Very Low
Rupture 15 5.00 Very Low Very Low Very Low
Crystal Associated Disease 10 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine whether Syk can modulate the inflammasome by directly interacting with its components, we immunoprecipitated Syk and then immunoblotted for potential partners associated with Syk by silver staining and western blotting (Fig. 8A).
Syk Binding (associated) of
1) Confidence 0.32 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
To examine whether Syk can modulate the inflammasome by directly interacting with its components, we immunoprecipitated Syk and then immunoblotted for potential partners associated with Syk by silver staining and western blotting (Fig. 8A).
Syk Binding (interacting) of
2) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
To examine whether Syk can modulate the inflammasome by directly interacting with its components, we immunoprecipitated Syk and then immunoblotted for potential partners associated with Syk by silver staining and western blotting (Fig. 8A).
Syk Binding (immunoprecipitated) of
3) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
For instance, we found some indication that Syk can interact with ASC, but not NLRP3.
Syk Neg (not) Binding (interact) of
4) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
These results indicate that Syk not only can associate with the inflammasome component but it can also modulate cathepsin B activation.


Syk Binding (associate) of
5) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.30 Pain Relevance 0.04

General Comments

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