INT278379

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Pstpip1, Mefv) cytoplasm (Pstpip1, Mefv) oxidoreductase activity (Pstpip1)
cell adhesion (Pstpip1) nucleus (Mefv) intracellular (Mefv)
Pstpip1 (Mus musculus)
Mefv (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 59 99.24 Very High Very High Very High
Arthritis 3 90.72 High High
abdominal pain 3 69.16 Quite High
anakinra 5 64.80 Quite High
Etanercept 1 51.56 Quite High
corticosteroid 3 46.16 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 30 100.00 Very High Very High Very High
INFLAMMATION 70 99.24 Very High Very High Very High
Acne 2 96.44 Very High Very High Very High
Ulcers 1 95.76 Very High Very High Very High
Arthritis 3 95.04 Very High Very High Very High
Pyoderma Gangrenosum 1 91.60 High High
Osteomyelitis 1 79.28 Quite High
Periostitis 1 78.08 Quite High
Abdominal Pain 3 69.16 Quite High
Splenomegaly 1 68.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, hyperphosphorylated PSTPIP1 (proline serine threonine phosphatase-interacting protein) was shown to interact with the pyrin protein [39], resulting in its conformational change and further its interaction with ASC [40].
PSTPIP1 Binding (interact) of pyrin protein
1) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Moreover, hyperphosphorylated PSTPIP1 (proline serine threonine phosphatase-interacting protein) was shown to interact with the pyrin protein [39], resulting in its conformational change and further its interaction with ASC [40].
proline serine threonine phosphatase-interacting protein Binding (interact) of pyrin protein
2) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Mutations in the proline-serine-threonine phosphatase interacting protein-1 are responsible for disease and are believed to affect interactions with the pyrin protein, resulting in IL-1-mediated inflammation [19•].
proline-serine-threonine phosphatase Binding (interactions) of pyrin protein associated with inflammation and disease
3) Confidence 0.02 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 2.02 Pain Relevance 0.48

General Comments

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