INT278388

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lyn) Golgi apparatus (Lyn) plasma membrane (Lyn)
nucleus (Lyn) enzyme binding (Lyn) kinase activity (Lyn)
Anatomy Link Frequency
THP-1 2
neutrophils 2
Msu (Mus musculus)
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 28.16 Quite Low
cytokine 20 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 63.68 Quite High
Parasitemia 8 42.68 Quite Low
Plasmodium Infection 34 32.84 Quite Low
Disease 12 28.52 Quite Low
INFLAMMATION 28 28.16 Quite Low
Infection 18 5.00 Very Low Very Low Very Low
Fever 12 5.00 Very Low Very Low Very Low
Rupture 6 5.00 Very Low Very Low Very Low
Crystal Associated Disease 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our hands, MSU did not induce Syk or Lyn phosphorylation in PMA-differentiated THP-1 cells nor in BMDM.
MSU Neg (nor) Positive_regulation (induce) of Phosphorylation (phosphorylation) of Lyn in THP-1
1) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.06 Pain Relevance 0
However, MSU was previously reported to trigger Syk phosphorylation in dendritic cells [35] and human neutrophils [36], as well as Lyn phosphorylation in neutrophils [37].
MSU Positive_regulation (trigger) of Phosphorylation (phosphorylation) of Lyn in neutrophils
2) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.06 Pain Relevance 0

General Comments

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