INT278389

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
spinal cord 1
Casp1 (Mus musculus)
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 1 100.00 Very High Very High Very High
Inflammation 61 96.56 Very High Very High Very High
Arthritis 2 89.36 High High
Neuropathic pain 2 55.52 Quite High
Peripheral nerve injury 1 53.68 Quite High
cytokine 24 11.68 Low Low
chemokine 7 5.00 Very Low Very Low Very Low
IPN 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 69 96.56 Very High Very High Very High
Nociception 13 91.60 High High
Arthritis 2 89.36 High High
Vibrio Infection 1 83.60 Quite High
Cancer 5 78.08 Quite High
Neuropathic Pain 2 55.52 Quite High
Nervous System Injury 1 52.80 Quite High
Plasmodium Infection 17 37.72 Quite Low
Death 1 29.56 Quite Low
Disease 7 8.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, activation of caspase-1 in the spinal cord has been associated with an increase of central IL-1?
caspase-1 Binding (associated) of IL-1 in spinal cord associated with spinal cord
1) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.66 Pain Relevance 0.36
, anti-human or murine caspase-1 and anti-Syk from Santa Cruz; True Blot anti-rabbit Ig, anti-phosphoY/HRP from eBioscience; PVDF from Bio-rad; anti-LAMP-1 Ab from Developmental Studies Hybridoma Bank at the University of Iowa; anti-human mature IL-1?
caspase-1 Binding (mature) of IL-1
2) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.16 Pain Relevance 0

General Comments

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