INT278396

Context Info Confidence 0.25 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.27 Pain Relevance 0

kinase activity (Syk) cytoplasm (Syk)

Anatomy Link Frequency neutrophils 2 Msu (Mus musculus) Syk (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 16 24.08 cytokine 20 5.00 Inflammatory response 8 5.00 chemokine 6 5.00 Inflammatory mediators 4 5.00 imagery 2 5.00 headache 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 4 79.08 Rupture 6 68.60 Stress 2 59.60 Parasitemia 8 38.60 Plasmodium Infection 34 28.76 Disease 12 24.44 INFLAMMATION 28 24.08 Infection 18 5.00 Fever 12 5.00 Crystal Associated Disease 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Even by extending the time-course of stimulation, MSU did not induce Syk phosphorylation (Fig S4A).

MSU Neg (not) Positive_regulation (induce) of Phosphorylation (phosphorylation) of Syk

1) Confidence 0.25 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.21 Pain Relevance 0

However, MSU was previously reported to trigger Syk phosphorylation in dendritic cells [35] and human neutrophils [36], as well as Lyn phosphorylation in neutrophils [37].

MSU Positive_regulation (trigger) of Phosphorylation (phosphorylation) of Syk in neutrophils

2) Confidence 0.23 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.06 Pain Relevance 0

General Comments

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