INT278398

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hps5, Nlrp3) pigmentation (Hps5)
Hps5 (Mus musculus)
Nlrp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 24 94.56 High High
Inflammatory response 12 87.52 High High
Inflammatory mediators 6 67.12 Quite High
cytokine 30 49.36 Quite Low
headache 3 24.92 Low Low
chemokine 9 8.08 Low Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Plasmodium Infection 51 99.62 Very High Very High Very High
Crystal Associated Disease 6 95.40 Very High Very High Very High
Disease 18 94.92 High High
INFLAMMATION 42 94.56 High High
Fever 18 90.32 High High
Parasitemia 12 87.04 High High
Stress 3 86.16 High High
Apoptosis 6 69.72 Quite High
Headache 3 24.92 Low Low
Anaemia 3 24.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, we found that Hz does not translocate from the phagosome/lysosome compartment to the cytoplasm, as it is located within LAMP-1-positive compartments, suggesting that Hz activated the NLRP3 inflammasome in an indirect manner.
Hz Positive_regulation (activated) of NLRP3
1) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.40 Pain Relevance 0.04
[6], we tested whether Hz can activate the NLRP3 inflammasome.
Hz Positive_regulation (activate) of NLRP3
2) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.61 Pain Relevance 0.08
Here we provide the first demonstration that the malaria pigment hemozoin (Hz) can also activate the NLRP3 inflammasome.
Hz Positive_regulation (activate) of NLRP3 associated with plasmodium infection
3) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.37 Pain Relevance 0.05

General Comments

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