INT278425

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tnfrsf4)
Anatomy Link Frequency
microglia 3
spinal cord 1
Tnfrsf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 108 99.48 Very High Very High Very High
Lasting pain 6 75.76 Quite High
Peripheral nerve injury 12 50.00 Quite Low
Neuropathic pain 15 48.88 Quite Low
Dorsal horn 6 28.36 Quite Low
Inflammation 8 19.36 Low Low
Central nervous system 11 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
analgesia 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 94 98.88 Very High Very High Very High
Increased Venous Pressure Under Development 3 87.40 High High
Nervous System Injury 48 80.72 Quite High
Gliosis 3 78.08 Quite High
Pain 11 74.88 Quite High
Ganglion Cysts 6 61.36 Quite High
Neuropathic Pain 18 48.88 Quite Low
Cancer 5 38.88 Quite Low
Necrosis 5 38.40 Quite Low
Injury 15 29.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To obtain an absolute quantitative measure of microgliosis we developed a flow cytometry based method for identification and quantification of microglia within dissected spinal cord tissue sections based on reactivity with OX42 and the macrophage marker antibody, ED9.
OX42 Binding (reactivity) of in spinal cord associated with spinal cord
1) Confidence 0.03 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.30 Pain Relevance 0.26
Quantification of microglia was based on reactivity with OX42 (CD11b/c) and ED9 (CD172a, SIRP).
OX42 Binding (reactivity) of in microglia
2) Confidence 0.02 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.09 Pain Relevance 0.03
By quantifying basal and postinjury changes to ED9 binding to OX42 positive cells, in parallel with changes to microglia numbers, we further validated ED9 as a novel tool for flow cytometry based identification of spinal cord microglia and their activation.
OX42 Binding (binding) of in microglia associated with spinal cord
3) Confidence 0.02 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.08 Pain Relevance 0.15
Monoclonal OX42 antibody that recognizes the expression of complement receptor 3 on the microglia was used to detect all status of microglia (from resting to fully activated status) in the retinal sections.
OX42 Binding (recognizes) of in microglia
4) Confidence 0.01 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 0.83 Pain Relevance 0

General Comments

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