INT278490

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv1) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1) cytoplasm (Faah)
Anatomy Link Frequency
brain 2
Lever 2
Faah (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 102 98.08 Very High Very High Very High
Inflammation 8 91.20 High High
Inflammatory mediators 10 73.84 Quite High
Action potential 2 63.76 Quite High
Potency 2 52.60 Quite High
Pain 2 52.48 Quite High
bradykinin 2 31.72 Quite Low
Cannabinoid 4 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 91.20 High High
Nociception 10 64.72 Quite High
Pain 2 52.48 Quite High
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, we found that inhibition of the anandamide-hydrolysing enzyme, fatty acid amide hydrolase (FAAH), which is also expressed by a major sub-population of TRPV1-expressing primary sensory neurons results in TRPV1 activity (Lever et al., 2009).
Negative_regulation (inhibition) of FAAH in Lever Positive_regulation (results) of TRPV1
1) Confidence 0.38 Published 2009 Journal Neuroscience Section Body Doc Link PMC2724038 Disease Relevance 0.34 Pain Relevance 0.31
However, the signal amplification process by NAPE-PLD may not be unique in capsaicin-sensitive primary sensory neurons, because increasing anandamide concentration, for example by inhibiting FAAH activity, also results in TRPV1 activity in the brain (Maione et al., 2006; Morgese et al., 2007).
Negative_regulation (inhibiting) of FAAH in brain Positive_regulation (results) of TRPV1 associated with qutenza
2) Confidence 0.38 Published 2009 Journal Neuroscience Section Body Doc Link PMC2724038 Disease Relevance 0.27 Pain Relevance 0.45

General Comments

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