INT278545

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.12
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN7A)
Anatomy Link Frequency
flagellum 2
sperm 2
SCN7A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.9 24 99.32 Very High Very High Very High
nav1.8 54 98.82 Very High Very High Very High
Nav1.7 42 98.32 Very High Very High Very High
Nav1.6 42 97.84 Very High Very High Very High
nav1.3 42 96.40 Very High Very High Very High
Nav1.2 30 95.92 Very High Very High Very High
Nav1.1 48 95.44 Very High Very High Very High
tetrodotoxin 54 92.08 High High
addiction 6 78.24 Quite High
Action potential 6 56.96 Quite High
Disease Link Frequency Relevance Heat
Sperm Disorder 90 59.28 Quite High
Nociception 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
subunits SCN1A (Nav1.1, 225 bp), SCN2A (Nav1.2, 297 bp), SCN3A (Nav1.3, 367 bp), SCN4A (Nav1.4, 317 bp), SCN5A (Nav1.5, 294 bp), SCN8A (Nav1.6, 207 bp), SCN9A (Nav1.7, 289 bp), SCN10A (Nav1.8, 347 bp), SCN11A (Nav1.9, 272 bp) and the related isoform SCN7A (Nax, 327 bp) were all expressed in human sperm cDNA (Fig 1).
Gene_expression (expressed) of Nax in sperm associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
1) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.96
subunits SCN1A (Nav1.1, 225 bp), SCN2A (Nav1.2, 297 bp), SCN3A (Nav1.3, 367 bp), SCN4A (Nav1.4, 317 bp), SCN5A (Nav1.5, 294 bp), SCN8A (Nav1.6, 207 bp), SCN9A (Nav1.7, 289 bp), SCN10A (Nav1.8, 347 bp), SCN11A (Nav1.9, 272 bp) and the related isoform SCN7A (Nax, 327 bp) were all expressed in human sperm cDNA (Fig 1).
Gene_expression (expressed) of SCN7A in sperm associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
2) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.96
The atypical isoform SCN7A (Nax) was present in the flagellum and in the equatorial segment of the head (Fig. 2).
Gene_expression (present) of Nax in flagellum
3) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.94
isoform, SCN7A (also known as Nax), has also been cloned and expressed [6,7].
Gene_expression (expressed) of SCN7A
4) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0.06 Pain Relevance 1.22
The atypical isoform SCN7A (Nax) was present in the flagellum and in the equatorial segment of the head (Fig. 2).
Gene_expression (present) of SCN7A in flagellum
5) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.94
isoform, SCN7A (also known as Nax), has also been cloned and expressed [6,7].
Gene_expression (expressed) of Nax
6) Confidence 0.58 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0.06 Pain Relevance 1.21

General Comments

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