INT278546

Context Info Confidence 0.03 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.19 Pain Relevance 1.10

cell differentiation (GNPTAB) Golgi apparatus (GNPTAB) nucleus (GNPTAB) transcription factor binding (GNPTAB)

Anatomy Link Frequency spermatozoa 1 GNPTAB (Homo sapiens)

Pain Link Frequency Relevance Heat Nav1.1 16 100.00 nav1.3 14 94.00 abdominal pain 5 87.80 Angina 6 86.32 headache 3 83.92 sodium channel 14 82.40 tetrodotoxin 18 5.00 nav1.8 18 5.00 Nav1.6 14 5.00 Nav1.7 14 5.00

Disease Link Frequency Relevance Heat Syndrome 82 100.00 Sperm Disorder 30 90.48 Exanthema 3 89.76 Respiratory Failure 5 89.52 Dyspnea 5 88.68 Abdominal Pain 5 87.80 Vomiting 15 87.16 Angina 7 86.32 Pain 9 85.84 Fatigue 5 85.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the case of Background Patient Generation, the information coming from Step One into Step Two is much richer: it contains a high level description of every patient visit including syndromes, sub-syndromes, and final ICD-9 codes (Figure 2).

Transcription (description) of ICD-9 associated with syndrome

1) Confidence 0.03 Published 2010 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2972239 Disease Relevance 1.72 Pain Relevance 0.26

The mRNAs that encode the different Nav alpha subunits (Nav1.1-1.9) were all expressed in capacitated human spermatozoa.

Transcription (expressed) of subunits in spermatozoa associated with nav1.1

2) Confidence 0.02 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2724540 Disease Relevance 0.24 Pain Relevance 0.41

The mRNAs of the auxiliary subunits beta1, beta3 and beta4 were also present.

Transcription (present) of subunits

3) Confidence 0.02 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2724540 Disease Relevance 0.24 Pain Relevance 0.43

General Comments

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