INT278610

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CDCA2, NR1H4) nucleoplasm (NR1H4) cytoplasm (CDCA2)
mitosis (CDCA2) signal transduction (NR1H4) nucleolus (CDCA2)
Anatomy Link Frequency
liver 1
CDCA2 (Homo sapiens)
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 9 95.44 Very High Very High Very High
agonist 13 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Van Bogaert's Disease 7 100.00 Very High Very High Very High
Hepatotoxicity 1 91.76 High High
Gallstones 2 88.76 High High
Syndrome 2 70.12 Quite High
Hyperbilirubinemia 1 68.08 Quite High
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The formation of chenodeoxycholic acid (CDCA) glucuronide by UGT1A3 has been shown to decrease farnesoid X receptor (FXR) activation by CDCA, the prototypical FXR ligand [99], suggesting that UGT1A3 induction in human liver would be expected to have down-stream consequences for an array of gene expression networks that are transcriptionally regulated by FXR.

4.2.

CDCA Negative_regulation (decrease) of FXR in liver associated with van bogaert's disease
1) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.62 Pain Relevance 0.13

General Comments

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