INT27864

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Context Info
Confidence 0.22
First Reported 1988
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 3.76
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 6
heart 3
hypothalamus 1
CNS 1
Sysbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 5 100.00 Very High Very High Very High
Morphine 3 100.00 Very High Very High Very High
opioid receptor 1 100.00 Very High Very High Very High
Ultiva 22 99.86 Very High Very High Very High
Central nervous system 10 99.68 Very High Very High Very High
antinociception 1 99.00 Very High Very High Very High
anesthesia 44 98.70 Very High Very High Very High
Clonidine 6 98.02 Very High Very High Very High
headache 3 92.72 High High
addiction 1 91.76 High High
Disease Link Frequency Relevance Heat
Ocular Hypertension 27 100.00 Very High Very High Very High
Stroke 2 100.00 Very High Very High Very High
Heart Rate Under Development 10 99.38 Very High Very High Very High
Neurologic Manifestations 1 98.32 Very High Very High Very High
Vomiting 3 93.24 High High
Headache 3 92.72 High High
Increased Venous Pressure Under Development 3 91.36 High High
Cv General 3 Under Development 2 90.60 High High
Myocardial Infarction 1 89.16 High High
Hemorrhage 8 84.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in supine systolic blood pressure (SSBP) from baseline to the end of the single-therapy phase were 10 mm Hg for the betaxolol and 16 mm Hg for the chlorthalidone group.
Regulation (Changes) of systolic blood pressure in blood
1) Confidence 0.22 Published 1989 Journal Arch. Intern. Med. Section Abstract Doc Link 2684073 Disease Relevance 0.07 Pain Relevance 0
Changes in heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and rate pressure product (RPP) were analyzed by analysis of variance (ANOVA).
Spec (analyzed) Regulation (Changes) of systolic arterial pressure in heart
2) Confidence 0.03 Published 1992 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815458 Disease Relevance 0.29 Pain Relevance 0.32
The purpose of this study was to determine whether oral clonidine premedication improves cardiovascular stability and/or reduces the requirements for drugs used to control systolic blood pressure (SBP) during elective craniotomies.
Regulation (control) of systolic blood pressure in blood associated with clonidine
3) Confidence 0.02 Published 1993 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 8400756 Disease Relevance 0 Pain Relevance 0.36
In this work we identified the systolic blood pressure as a covariate affecting metabolic clearance.
Regulation (affecting) of systolic blood pressure in blood
4) Confidence 0.01 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC2889282 Disease Relevance 0.12 Pain Relevance 0.05
We investigated the effects of these analogs on the opioid receptors affinity, guinea pig ileum (GPI) and mouse vas deferens (MVD) activity, system arterial pressure (SAP), heart rate (HR), antinociception and colonic motility.
Spec (investigated) Regulation (effects) of system arterial pressure in heart associated with antinociception and opioid receptor
5) Confidence 0.01 Published 2007 Journal Peptides Section Abstract Doc Link 17276550 Disease Relevance 0 Pain Relevance 0.22
Compared to placebo, at supine rest, flosequinan significantly increased heart rate (HR) by 5 beats.min-1, but had no effect on cardiac output (CO), stroke volume (SV) and mean blood pressure (MBP).
Neg (no) Regulation (effect) of mean blood pressure in blood associated with heart rate under development and stroke
6) Confidence 0.01 Published 1994 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 7957523 Disease Relevance 0.85 Pain Relevance 0.18
In the patients with poor outcomes, the value of stump pressure (SP) was significantly lower.
Regulation (value) of stump pressure
7) Confidence 0.01 Published 2002 Journal Masui Section Abstract Doc Link 12134648 Disease Relevance 0.17 Pain Relevance 0.08
The aim of this study was to either confirm or repudiate the findings of previous authors and to investigate the effects of the three types of anesthesia in the surgical field of ESS, with total intravenous anesthesia (TIVA) with propofol/remifentanil, balanced general anesthesia with sevoflurane/remifentanil and desflurane/remifentanil under controlled mean blood pressure (MBP) and heart rate (HR).


Regulation (controlled) of mean blood pressure in heart associated with anesthesia and ultiva
8) Confidence 0.00 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC3022129 Disease Relevance 0.46 Pain Relevance 1.16
The effects of naloxone and morphine on mean arterial blood pressure (MBP) and heart rate (HR) responses to angiotensin II (AII) were studied in conscious cynomolgus monkeys.
Regulation (effects) of mean arterial blood pressure in blood associated with narcan and morphine
9) Confidence 0.00 Published 1988 Journal Life Sci. Section Abstract Doc Link 3398708 Disease Relevance 0 Pain Relevance 0.40
We examined the changes in heart rate (HR), mean blood pressure (mBP), the total score of QTc interval on a 12-lead electrocardiogram (sigma QTc), and ST-T segment, before and after drug administration.
Spec (examined) Regulation (changes) of mean blood pressure in blood
10) Confidence 0.00 Published 1998 Journal Heart Vessels Section Abstract Doc Link 10483772 Disease Relevance 0.18 Pain Relevance 0.09
[New experimental model of central regulation of intraocular pressure].
Regulation (regulation) of intraocular pressure associated with ocular hypertension
11) Confidence 0.00 Published 1993 Journal Nippon Ganka Gakkai Zasshi Section Title Doc Link 8393266 Disease Relevance 0.71 Pain Relevance 0.18
We investigated the effect on the intraocular pressure (IOP) of microiontophoretic injection of oxytocin (OXT) into the cat hypothalamus, to elucidate the mechanisms of IOP regulation by the central nervous system (CNS).
Regulation (regulation) of intraocular pressure in hypothalamus associated with central nervous system and ocular hypertension
12) Confidence 0.00 Published 1993 Journal Nippon Ganka Gakkai Zasshi Section Abstract Doc Link 8393266 Disease Relevance 0.46 Pain Relevance 0.19
We investigated the effect on the intraocular pressure (IOP) of microiontophoretic injection of oxytocin (OXT) into the cat hypothalamus, to elucidate the mechanisms of IOP regulation by the central nervous system (CNS).
Spec (investigated) Regulation (effect) of intraocular pressure in CNS associated with central nervous system and ocular hypertension
13) Confidence 0.00 Published 1993 Journal Nippon Ganka Gakkai Zasshi Section Abstract Doc Link 8393266 Disease Relevance 0.44 Pain Relevance 0.18

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