INT278671

Context Info Confidence 0.05 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.57 Pain Relevance 0.07

cytosol (SULT1A2) small molecule metabolic process (SULT1A2) cytoplasm (SULT1A2)

Anatomy Link Frequency keratinocyte 6 SULT1A2 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 39 83.88 Bile 27 58.76 Kinase C 12 5.00 Inflammation 6 5.00 Paracetamol 6 5.00 dexamethasone 3 5.00 Morphine 3 5.00 Opioid 3 5.00

Disease Link Frequency Relevance Heat Cancer 3 87.60 Van Bogaert's Disease 21 77.84 Targeted Disruption 6 70.64 Wound Healing 3 65.92 Gallstones 6 60.08 Toxicity 6 59.32 Sprains And Strains 6 5.00 Syndrome 6 5.00 INFLAMMATION 6 5.00 Insulin Resistance 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Exposure of fetal rat skin explants to air caused the accelerated expression of cholesterol sulfotransferase along with several other markers of keratinocyte differentiation, including filaggrin, loricrin and involucrin [61].

Positive_regulation (caused) of Gene_expression (expression) of sulfotransferase in keratinocyte

1) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.15 Pain Relevance 0

Particularly in keratinocytes which rely on lipid signaling for the progression of programmed cellular differentiation, the inducible expression of cholesterol sulfotransferase (SULT2B1b) by PPAR activators has been demonstrated.

Positive_regulation (inducible) of Gene_expression (expression) of sulfotransferase in keratinocytes

2) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.27 Pain Relevance 0.07

Exposure of fetal rat skin explants to air caused the accelerated expression of cholesterol sulfotransferase along with several other markers of keratinocyte differentiation, including filaggrin, loricrin and involucrin [61].

Positive_regulation (accelerated) of Gene_expression (expression) of sulfotransferase in keratinocyte

3) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.15 Pain Relevance 0

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