INT278674

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.04
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT2A1) small molecule metabolic process (SULT2A1) cytoplasm (SULT2A1)
Anatomy Link Frequency
liver 2
SULT2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 8 99.98 Very High Very High Very High
agonist 104 99.16 Very High Very High Very High
Bile 72 70.56 Quite High
depression 12 42.72 Quite Low
Kinase C 32 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
Paracetamol 16 5.00 Very Low Very Low Very Low
Morphine 8 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 104 93.80 High High
Fatigue 16 86.56 High High
Targeted Disruption 16 86.00 High High
Van Bogaert's Disease 56 70.04 Quite High
Gallstones 16 52.28 Quite High
Frailty 2 51.64 Quite High
Toxicity 16 51.52 Quite High
Obesity 16 50.04 Quite High
Depression 12 42.72 Quite Low
Stress 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our laboratory has demonstrated that human hepatic SULT2A1 expression is increased by PPAR?
Positive_regulation (by) of Gene_expression (expression) of SULT2A1
1) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.17
-inducible human hepatic SULT2A1 expression occurs through a distal PPRE in the 5?
Positive_regulation (inducible) of Gene_expression (expression) of SULT2A1
2) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.26 Pain Relevance 0.06
-inducible human hepatic SULT2A1 expression occurs through a distal PPRE in the 5?
Positive_regulation (occurs) of Gene_expression (expression) of SULT2A1
3) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.26 Pain Relevance 0.04
GR-activating concentrations of glucocorticoid transactivated SULT2A transcription indirectly, through intermediary steps involving GR-inducible liver-enriched CCAAT enhancer binding protein [128], while pharmacological concentrations of dexamethasone induced rat hepatic SULT2A expression via a PXR-mediated mechanism [127].
Positive_regulation (induced) of Gene_expression (expression) of SULT2A in liver associated with dexamethasone
4) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.08
Analysis of a series of SULT2A1 5?
Positive_regulation (series) of Gene_expression (series) of SULT2A1
5) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.08
Our previous investigations suggested roles for both the glucocorticoid receptor (GR) and the pregnane X receptor (PXR) in the mediation of glucocorticoid-inducible rat hepatic SULT2A expression [127].
Positive_regulation (inducible) of Gene_expression (expression) of SULT2A
6) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.05 Pain Relevance 0.07
Treatment with PXR-activating concentrations of rifampicin causes PXR-dependent suppression of SULT2A1 expression, whereas treatment with higher rifampicin concentrations induces SULT2A1 expression through a PXR-independent mechanism [131].
Positive_regulation (induces) of Gene_expression (expression) of SULT2A1
7) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.07
is a positive regulator of SULT2A1 expression, and both the suppressive and activating effects of rifampicin appear to be transduced through interactions with HNF4?
Positive_regulation (regulator) of Gene_expression (expression) of SULT2A1
8) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.07
This may be interpreted as the fact that the acetylcholinergic effect of galantamine facilitates the release of CRH hormone and in turn, causes elevated DHEAS levels to decrease through recovering the existing tentative disturbance in metabolic shift from cortisol to DHEAS.
Positive_regulation (decrease) of Gene_expression (levels) of DHEAS
9) Confidence 0.24 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.74 Pain Relevance 0
This may be interpreted as the fact that the acetylcholinergic effect of galantamine facilitates the release of CRH hormone and in turn, causes elevated DHEAS levels to decrease through recovering the existing tentative disturbance in metabolic shift from cortisol to DHEAS.
Positive_regulation (elevated) of Gene_expression (levels) of DHEAS
10) Confidence 0.24 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.73 Pain Relevance 0

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