INT278678

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (UGT1A1) endoplasmic reticulum (UGT1A1) enzyme binding (UGT1A1)
Anatomy Link Frequency
hepatocytes 2
UGT1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 55.20 Quite High
agonist 26 5.00 Very Low Very Low Very Low
Bile 18 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 92.08 High High
Sprains And Strains 4 35.40 Quite Low
Van Bogaert's Disease 14 12.88 Low Low
Toxicity 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Gallstones 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 2 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a study using antipeptide antibodies to examine the effects of drug treatments on rat hepatic microsomal UGT levels, clofibrate treatment was found to increase the immunoreactive protein levels of UGT1A1 and UGT1A5 (termed UGT1B1 and UGT1B5 in that study) along with bilirubin UGT activity [110].
Positive_regulation (increase) of Gene_expression (levels) of UGT1A1
1) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.06
In a recent study by Senekeo-Effenberger et al. [125], Wy-14,643 treatment of primary cultured human hepatocytes increased the levels of UGT1A1, UGT1A3, UGT1A4, and UGT1A6, but not UGT1A9, mRNAs.
Positive_regulation (increased) of Gene_expression (levels) of UGT1A1 in hepatocytes
2) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.09 Pain Relevance 0

General Comments

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