INT278688

Context Info Confidence 0.04 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.69 Pain Relevance 0.54

mitochondrion (MTX1) endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)

Anatomy Link Frequency joints 2 MTX1 (Homo sapiens) SOAT1 (Homo sapiens)

Pain Link Frequency Relevance Heat methotrexate 14 100.00 rheumatoid arthritis 77 84.72 Arthritis 2 76.40 Inflammation 13 71.60 cytokine 8 70.56 Leflunomide 15 60.84 metalloproteinase 1 35.12 Pain 2 23.80 corticosteroid 3 21.72 Potency 1 19.60

Disease Link Frequency Relevance Heat Disease 29 99.64 Rheumatoid Arthritis 122 84.72 Experimental Arthritis 1 76.40 INFLAMMATION 12 71.60 Pressure And Volume Under Development 2 24.32 Pain 2 23.80 Frailty 34 5.00 Autoimmune Disease 7 5.00 Disease Progression 6 5.00 Arthritis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MTX reduces JAK/STAT activation within the joints [70].

MTX Negative_regulation (reduces) of Positive_regulation (activation) of STAT in joints associated with methotrexate

1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.69 Pain Relevance 0.54

General Comments

This test has worked.