INT278689

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.79
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK8) mitochondrion (MAPK8) intracellular (TNF)
extracellular matrix organization (TNF) response to stress (MAPK8) cytoplasm (MAPK8)
TNF (Homo sapiens)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 98.16 Very High Very High Very High
cytokine 8 97.64 Very High Very High Very High
methotrexate 14 90.92 High High
rheumatoid arthritis 77 72.92 Quite High
Arthritis 2 64.60 Quite High
Leflunomide 15 49.04 Quite Low
Potency 1 44.32 Quite Low
metalloproteinase 1 23.32 Low Low
Pain 2 12.00 Low Low
corticosteroid 3 9.92 Low Low
Disease Link Frequency Relevance Heat
Disease 29 98.44 Very High Very High Very High
INFLAMMATION 12 98.16 Very High Very High Very High
Rheumatoid Arthritis 122 72.92 Quite High
Experimental Arthritis 1 64.60 Quite High
Pressure And Volume Under Development 2 12.52 Low Low
Pain 2 12.00 Low Low
Frailty 34 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
Disease Progression 6 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF activates multiple kinases (p38, ERK, JNK) and will induce the expression of other pro-inflammatory cytokines that, in turn, invoke pro-inflammatory signaling events associated with kinase activation.
TNF Positive_regulation (activates) of JNK associated with inflammation and cytokine
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.79 Pain Relevance 0.56

General Comments

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