INT278690

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (LEF1, IK) histone binding (LEF1) DNA binding (LEF1)
cell-cell signaling (IK) cytoplasm (LEF1) extracellular space (IK)
Anatomy Link Frequency
joints 2
LEF1 (Homo sapiens)
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 15 100.00 Very High Very High Very High
methotrexate 14 100.00 Very High Very High Very High
cytokine 8 100.00 Very High Very High Very High
corticosteroid 3 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
metalloproteinase 1 83.52 Quite High
Inflammation 13 80.88 Quite High
rheumatoid arthritis 77 74.64 Quite High
Arthritis 2 50.00 Quite Low
Osteoarthritis 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 100.00 Very High Very High Very High
Pressure And Volume Under Development 2 100.00 Very High Very High Very High
INFLAMMATION 12 80.88 Quite High
Rheumatoid Arthritis 122 74.64 Quite High
Disease Progression 6 73.08 Quite High
Disease 29 52.84 Quite High
Frailty 34 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LEF, MTX and corticosteroids are broad immunosuppressive agents that reduce pain and swelling of affected joints, reduce cytokine production and limit radiological damage [50], [51], [52], [53], [54], [55].
LEF Negative_regulation (reduce) of Gene_expression (production) of cytokine in joints associated with pain, pressure and volume under development, corticosteroid, leflunomide, methotrexate and cytokine
1) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.66 Pain Relevance 0.83

General Comments

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