INT278697

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (LEF1, STAT6) nucleus (LEF1, STAT6) histone binding (LEF1)
DNA binding (LEF1) signal transducer activity (STAT6) cytosol (STAT6)
Anatomy Link Frequency
B cells 1
LEF1 (Homo sapiens)
STAT6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 15 100.00 Very High Very High Very High
cytokine 8 95.84 Very High Very High Very High
Inflammation 13 95.48 Very High Very High Very High
metalloproteinase 1 94.36 High High
Pain 2 83.04 Quite High
corticosteroid 3 80.96 Quite High
methotrexate 14 80.16 Quite High
rheumatoid arthritis 77 54.48 Quite High
Arthritis 2 50.00 Quite Low
Osteoarthritis 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 95.48 Very High Very High Very High
Pressure And Volume Under Development 2 83.56 Quite High
Pain 2 83.04 Quite High
Rheumatoid Arthritis 122 54.48 Quite High
Disease Progression 6 52.92 Quite High
Disease 29 32.68 Quite Low
Experimental Arthritis 1 32.00 Quite Low
Frailty 34 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with published data [63], we provide evidence that LEF reduces p-STAT6 levels in CD20+ B cells, which may direct reductions in antibody production.
LEF Negative_regulation (reduces) of p-STAT6 in B cells associated with leflunomide
1) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.44 Pain Relevance 0.78

General Comments

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