INT278709

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.91
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CBL) plasma membrane (CBL) nucleus (CBL)
ligase activity (CBL) cytoplasm (CBL) signal transducer activity (CBL)
CBL (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 96 99.24 Very High Very High Very High
Inflammation 40 77.20 Quite High
cytokine 24 74.16 Quite High
rheumatoid arthritis 231 73.56 Quite High
tolerance 3 60.48 Quite High
Arthritis 8 50.00 Quite Low
Inflammatory response 3 33.72 Quite Low
Leflunomide 45 5.00 Very Low Very Low Very Low
methotrexate 42 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 102 99.24 Very High Very High Very High
Rheumatoid Arthritis 366 98.96 Very High Very High Very High
Disease 120 96.20 Very High Very High Very High
Diabetes Mellitus 22 95.52 Very High Very High Very High
Disease Progression 18 89.76 High High
Autoimmune Disease 21 85.36 High High
Arthropathy 3 77.76 Quite High
INFLAMMATION 37 77.20 Quite High
Arthritis 12 52.68 Quite High
Metabolic Syndrome 1 48.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific signaling effectors (AKT, CBL, JNK, PLC-?
Gene_expression (effectors) of CBL
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.29 Pain Relevance 0.30
The MFI values of a subset of these effectors, p-AKT, p-CBL and p-JNK, were consistently higher in all three cell populations in ERA patient PBMCs compared to OA patient PBMCs.
Gene_expression (values) of CBL associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.48 Pain Relevance 0.36
The MFI levels for p-AKT, p-CBL and p-JNK were statistically higher (p<0.05) in ERA patient PBMCs compared with OA patient PBMCs, in the CD4+, CD8+ and CD20+ compartments (Figure 3).
Gene_expression (levels) of CBL associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.87 Pain Relevance 0.19
Db/db mice lack a functioning leptin receptor resulting in defective leptin-mediated signal transduction.
Gene_expression (resulting) of signal transduction
4) Confidence 0.04 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2948926 Disease Relevance 0.27 Pain Relevance 0

General Comments

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