INT278710

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 15 100.00 Very High Very High Very High
methotrexate 14 100.00 Very High Very High Very High
corticosteroid 3 100.00 Very High Very High Very High
Pain 2 93.04 High High
cytokine 8 89.44 High High
rheumatoid arthritis 77 78.64 Quite High
metalloproteinase 1 71.44 Quite High
Inflammation 13 68.80 Quite High
Arthritis 2 50.00 Quite Low
Osteoarthritis 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 93.04 High High
Pressure And Volume Under Development 2 92.32 High High
Rheumatoid Arthritis 122 78.64 Quite High
Disease Progression 6 77.08 Quite High
INFLAMMATION 12 68.80 Quite High
Disease 29 56.84 Quite High
Frailty 34 5.00 Very Low Very Low Very Low
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although in our study cohort the majority of patients were on multiple medications (Table S1), data analysis distinguished the contributions of LEF, corticosteroids, MTX and anti-TNF therapy as signature reductions in phosphorylation profiles.
Phosphorylation (phosphorylation) of LEF associated with corticosteroid, leflunomide and methotrexate
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.76 Pain Relevance 0.82

General Comments

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