INT278712

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.22
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (STAT4) nucleolus (STAT4) nucleus (STAT4)
cytoplasm (STAT4) signal transducer activity (STAT4)
Anatomy Link Frequency
T cells 1
STAT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 154 99.80 Very High Very High Very High
Arthritis 4 98.76 Very High Very High Very High
Leflunomide 30 93.76 High High
Inflammation 26 90.80 High High
methotrexate 28 77.76 Quite High
cytokine 16 69.52 Quite High
metalloproteinase 2 68.04 Quite High
Pain 4 56.72 Quite High
corticosteroid 6 54.64 Quite High
Osteoarthritis 64 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 244 99.80 Very High Very High Very High
Experimental Arthritis 2 99.28 Very High Very High Very High
INFLAMMATION 24 90.80 High High
Pressure And Volume Under Development 4 57.24 Quite High
Pain 4 56.72 Quite High
Disease 58 50.88 Quite High
Disease Progression 12 26.60 Quite Low
Frailty 68 5.00 Very Low Very Low Very Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, p-STAT4 levels were dramatically reduced in both the CD4+ and CD8+ T cells in patients on steroid therapy.
Negative_regulation (reduced) of STAT4 in T cells
1) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.60 Pain Relevance 0.74
Certainly, STAT4 has been associated with an increased risk of RA and mice lacking STAT4 are resistant to experimental arthritis [68].
Negative_regulation (lacking) of STAT4 associated with rheumatoid arthritis, experimental arthritis and arthritis
2) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.62 Pain Relevance 0.55

General Comments

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