INT278715

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 5.43
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
Anatomy Link Frequency
B cells 1
nucleus 1
fin 1
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 30 100.00 Very High Very High Very High
Inflammation 26 97.16 Very High Very High Very High
cytokine 16 95.84 Very High Very High Very High
metalloproteinase 7 94.36 High High
Pain 4 83.04 Quite High
corticosteroid 6 80.96 Quite High
methotrexate 28 80.16 Quite High
rheumatoid arthritis 154 76.08 Quite High
Arthritis 4 71.60 Quite High
imagery 7 67.52 Quite High
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 532 99.92 Very High Very High Very High
Colon Cancer 36 98.36 Very High Very High Very High
Repression 5 98.26 Very High Very High Very High
Cancer 114 97.24 Very High Very High Very High
INFLAMMATION 36 97.16 Very High Very High Very High
Malignant Neoplastic Disease 33 92.96 High High
Apoptosis 171 91.56 High High
Pressure And Volume Under Development 4 83.56 Quite High
Pain 4 83.04 Quite High
Rheumatoid Arthritis 244 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Lef1 from mRNAs lacking 3'UTR recognition elements can rescue the effects of excess miR-203, demonstrating that these effects are due to specific regulation of Lef1 by miR-203.
Gene_expression (Expression) of Lef1
1) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.37 Pain Relevance 0
-catenin and other genes (543 genes) by text mining. 213 genes (including Tcf4 and Lef, ect.) interact with ?
Gene_expression (ect.) of Lef
2) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.28 Pain Relevance 0
-catenin accumulates in the nucleus, Groucho/TLE is displaced from Tcf/Lef by ?
Gene_expression (/) of Lef in nucleus
3) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.16 Pain Relevance 0
Further, repression of Lef1 by miR-203 blocks fin regeneration, whereas loss of miR-203 results in excess Lef1 levels and fin overgrowth.


Gene_expression (levels) of Lef1 in fin associated with repression
4) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.25 Pain Relevance 0
-catenin and other genes (543 genes) by text mining. 213 genes (including Tcf4 and Lef, ect.) interact with ?
Gene_expression (including) of Lef
5) Confidence 0.29 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.29 Pain Relevance 0
To determine the ability of EA to alter LEF-1, cyclin D1, fibronectin and Fzd5 transcript expression, CLL cells from three patients were treated with the drug for 16 h, and then analyzed by real-time PCR.
Gene_expression (expression) of LEF associated with chronic lymphoid leukemia
6) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.62 Pain Relevance 0
As shown in Figure 3, EA decreased LEF-1, cyclin D1 and fibronectin mRNA expression in a concentration-dependent fashion in CLL cells.
Gene_expression (expression) of LEF associated with chronic lymphoid leukemia
7) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.44 Pain Relevance 0
It has been demonstrated that LEF-1 is constitutively associated with ?
Gene_expression (demonstrated) of LEF
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.51 Pain Relevance 0
Experiments with real-time PCR demonstrated that treatment with EA caused a dose-dependent decline in the expression of three Wnt target genes, LEF-1, cyclin D1 and fibronectin, which reflects EA inhibition of Wnt/?
Gene_expression (expression) of LEF
9) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.29 Pain Relevance 0
The orphan Wnt receptor ROR1, whose promoter contains multiple LEF-1 regulatory motifs, is also highly expressed in CLL.
Gene_expression (expressed) of LEF associated with chronic lymphoid leukemia
10) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.83 Pain Relevance 0
1000), anti-LEF-1 antibody (1?
Gene_expression (antibody) of anti-LEF-1
11) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.13 Pain Relevance 0.03
For CLL cells, lysates of 1 to 2×107 cells were incubated with anti-LEF-1 antibody at a 1?
Gene_expression (antibody) of anti-LEF-1 associated with chronic lymphoid leukemia
12) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.25 Pain Relevance 0
Additionally, LEF inhibits Th17 generation through inhibition of p-STAT6 [67] and we also observed reductions in p-STAT6 levels in patients on these medications.
Gene_expression (generation) of LEF associated with leflunomide
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.57 Pain Relevance 0.73
Consistent with published data [63], we provide evidence that LEF reduces p-STAT6 levels in CD20+ B cells, which may direct reductions in antibody production.
Gene_expression (reduces) of LEF in B cells associated with leflunomide
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.44 Pain Relevance 0.78

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