INT278717

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.17
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (STAT4) nucleolus (STAT4) nucleus (STAT4)
cytoplasm (STAT4) signal transducer activity (STAT4)
Anatomy Link Frequency
joints 1
T cells 1
STAT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 4 99.72 Very High Very High Very High
rheumatoid arthritis 154 97.20 Very High Very High Very High
Leflunomide 30 93.76 High High
Inflammation 26 90.80 High High
methotrexate 28 82.80 Quite High
cytokine 16 69.52 Quite High
metalloproteinase 2 68.04 Quite High
Pain 4 56.72 Quite High
corticosteroid 6 54.64 Quite High
Osteoarthritis 64 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 2 99.72 Very High Very High Very High
Rheumatoid Arthritis 244 98.88 Very High Very High Very High
INFLAMMATION 24 90.80 High High
Pressure And Volume Under Development 4 57.24 Quite High
Pain 4 56.72 Quite High
Disease 58 55.92 Quite High
Disease Progression 12 26.60 Quite Low
Frailty 68 5.00 Very Low Very Low Very Low
Autoimmune Disease 14 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STAT4 expression in joints of patients with ERA has been reported [69] and here we show that prednisone may function in part by blocking STAT4 activation.
Gene_expression (expression) of STAT4 in joints associated with rheumatoid arthritis
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.58 Pain Relevance 0.55
Notably, p-STAT4 levels were dramatically reduced in both the CD4+ and CD8+ T cells in patients on steroid therapy.
Gene_expression (levels) of STAT4 in T cells
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.59 Pain Relevance 0.71

General Comments

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