INT278722

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Context Info
Confidence 0.10
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.19
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ERAL1) RNA binding (ERAL1) rRNA binding (ERAL1)
intracellular (ERAL1) ribosome biogenesis (ERAL1)
ERAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 231 99.56 Very High Very High Very High
Inflammation 39 97.92 Very High Very High Very High
tolerance 3 92.16 High High
Leflunomide 45 81.32 Quite High
Inflammatory response 3 78.96 Quite High
cINOD 6 75.60 Quite High
Arthritis 6 75.00 Quite High
cytokine 24 74.16 Quite High
methotrexate 42 72.96 Quite High
Osteoarthritis 96 62.96 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 366 100.00 Very High Very High Very High
Disease 87 99.04 Very High Very High Very High
Arthritis 9 97.92 Very High Very High Very High
Autoimmune Disease 21 96.08 Very High Very High Very High
INFLAMMATION 36 78.60 Quite High
Frailty 102 62.96 Quite High
Arthropathy 3 57.92 Quite High
Apoptosis 3 53.92 Quite High
Disease Progression 18 34.40 Quite Low
Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next examined the effects of specific disease modifying anti-rheumatic drugs (DMARDs) on the phosphorylation status of 12 phospho-epitopes in ERA patients.
Phosphorylation (phosphorylation) of ERA associated with rheumatoid arthritis and disease
1) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.76 Pain Relevance 0.40
Notably, there were no significant differences in phosphorylation profiles between ERA and established RA PBMCs.
Phosphorylation (phosphorylation) of ERA associated with rheumatoid arthritis
2) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.35 Pain Relevance 0.56
Notably, phosphorylation of these signaling effectors did not distinguish ERA from late RA, suggesting that the activation status of discrete cell populations is already established early in disease.
Phosphorylation (phosphorylation) of ERA associated with rheumatoid arthritis and disease
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2724743 Disease Relevance 1.08 Pain Relevance 0.26

General Comments

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