INT278723

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.74
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

HIST2H3C (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 96.52 Very High Very High Very High
Bioavailability 12 80.84 Quite High
rheumatoid arthritis 77 77.88 Quite High
Osteoarthritis 32 72.88 Quite High
Arthritis 2 50.00 Quite Low
Leflunomide 15 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 37 99.62 Very High Very High Very High
Cancer 94 99.36 Very High Very High Very High
Apoptosis 27 98.90 Very High Very High Very High
Rheumatoid Arthritis 124 91.32 High High
Lymphatic System Cancer 8 89.04 High High
Disease 51 82.44 Quite High
Shock 2 81.84 Quite High
Frailty 34 72.88 Quite High
Disease Progression 6 67.76 Quite High
Repression 2 63.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As other HDACIs, at nanomolar concentrations they induce growth arrest and apoptosis of a variety of cancer and leukemia cell types, cause hyperacetylation of H3 and H4 histones, increase p21 levels, and induce cell cycle G1 phase accumulation [122].
H3 Binding (hyperacetylation) of associated with leukemia, cancer and apoptosis
1) Confidence 0.04 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.59 Pain Relevance 0.04
H3 phosphorylation is associated with gene transcription and cell division [36] and the correlation with MDGA score or DAS may point toward expansion of these cell populations.
H3 Binding (associated) of
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.90 Pain Relevance 0.24
HMTs methylate specific lysine or arginine residues on nucleosomal histone H3, which in the case of lysine 9 (K9) methylation allows the recruitment of the heterochromatin protein 1 (HP1) stabilizing an inactive condensed chromatin [3].
H3 Binding (recruitment) of
3) Confidence 0.04 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.25 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox