INT278727

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 30 100.00 Very High Very High Very High
Inflammation 26 97.16 Very High Very High Very High
rheumatoid arthritis 154 77.60 Quite High
cytokine 16 75.88 Quite High
metalloproteinase 2 74.40 Quite High
Arthritis 4 73.12 Quite High
Pain 4 63.08 Quite High
corticosteroid 6 61.00 Quite High
methotrexate 28 60.20 Quite High
Osteoarthritis 64 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 76 98.36 Very High Very High Very High
INFLAMMATION 25 97.16 Very High Very High Very High
Rheumatoid Arthritis 244 77.60 Quite High
Experimental Arthritis 2 74.16 Quite High
Death 5 64.08 Quite High
Pressure And Volume Under Development 4 63.60 Quite High
Pain 4 63.08 Quite High
Toxicity 3 50.00 Quite Low
Cancer 7 42.48 Quite Low
Disease Progression 12 32.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 3, EA decreased LEF-1, cyclin D1 and fibronectin mRNA expression in a concentration-dependent fashion in CLL cells.
Negative_regulation (decreased) of Gene_expression (expression) of LEF associated with chronic lymphoid leukemia
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.44 Pain Relevance 0
Additionally, LEF inhibits Th17 generation through inhibition of p-STAT6 [67] and we also observed reductions in p-STAT6 levels in patients on these medications.
Negative_regulation (inhibits) of Gene_expression (generation) of LEF associated with leflunomide
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.57 Pain Relevance 0.73
Additionally, LEF inhibits Th17 generation through inhibition of p-STAT6 [67] and we also observed reductions in p-STAT6 levels in patients on these medications.
Negative_regulation (inhibition) of Gene_expression (generation) of LEF associated with leflunomide
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.58 Pain Relevance 0.73

General Comments

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