INT278754

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

plasma membrane (OR51S1) nucleus (HOXA9) signal transducer activity (OR51S1) cytoplasm (HOXA9)

HOXA9 (Homo sapiens) OR51S1 (Homo sapiens) HOXA9 - N51S (1) OR51S1 - N51S (2)

Pain Link Frequency Relevance Heat cINOD 6 5.00 aspirin 4 5.00 cytokine 4 5.00

Disease Link Frequency Relevance Heat Myeloid Leukemia 12 17.68 Chronic Lymphoid Leukemia 4 15.80 Hematologic Neoplasms 4 14.24 Leukemia 16 5.00 Cancer 14 5.00 Cytomegalovirus Infection 6 5.00 Lymphatic System Cancer 4 5.00 Repression 2 5.00 Adhesions 2 5.00 INFLAMMATION 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Based on gene expression analysis, a group of 46 probe sets were identified that show similar dysregulation by NUP98-HOXA9 and NUP98-HOXA9/N51S (Fig. 11A and Tables S2–S5) and therefore presumably do not require direct DNA binding by the homeodomain for their dysregulation.

HOXA9 (N51S) Regulation (dysregulation) of N51S (N51S)

1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0

Based on gene expression analysis, a group of 46 probe sets were identified that show similar dysregulation by NUP98-HOXA9 and NUP98-HOXA9/N51S (Fig. 11A and Tables S2–S5) and therefore presumably do not require direct DNA binding by the homeodomain for their dysregulation.

HOXA9 Regulation (dysregulation) of N51S (N51S)

2) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0

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