INT27878

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Context Info
Confidence 0.26
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 20.62
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (FCGR1B)
Anatomy Link Frequency
WBC 3
lymphocyte 3
monocytes 2
B-cells 2
platelet 2
FCGR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 272 96.00 Very High Very High Very High
Etanercept 55 93.20 High High
Arthritis 2 83.96 Quite High
Osteoarthritis 98 80.64 Quite High
corticosteroid 23 79.32 Quite High
Infliximab 5 77.76 Quite High
Central nervous system 23 74.56 Quite High
cytokine 53 72.36 Quite High
Inflammation 112 71.96 Quite High
intrathecal 4 60.80 Quite High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 351 99.58 Very High Very High Very High
Systemic Sclerosis 98 98.88 Very High Very High Very High
Meningitis 204 98.48 Very High Very High Very High
Contagious Ecthyma 122 98.44 Very High Very High Very High
Proteinuria 119 98.12 Very High Very High Very High
Shock 2 97.96 Very High Very High Very High
Systemic Lupus Erythematosus 130 97.42 Very High Very High Very High
Epstein-barr Virus 94 97.24 Very High Very High Very High
Infection 356 97.08 Very High Very High Very High
Disease 241 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that 2 mg inhaled FP decreased the expression of CD11b, mCD14, CD16, CD64, CD86, and HLA-DR on sputum monocytic cells after O3 challenge compared with placebo treatment.
Gene_expression (expression) of CD64 in sputum
1) Confidence 0.26 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.07 Pain Relevance 0
RIII, CD64/Fc?
Gene_expression (/) of CD64
2) Confidence 0.22 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.55 Pain Relevance 0.10
RIII, CD64/Fc?
Gene_expression (/) of CD64
3) Confidence 0.22 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0 Pain Relevance 0
In labouring women, we observed a significant increase in the proportion of monocytes expressing each of the cell surface markers CD64 (P < 0.01), CD11b (P < 0.001) and CD62L (P < 0.05) compared with monocytes from non-labouring women (Fig. 6A, B and C).
Gene_expression (expressing) of CD64 in monocytes
4) Confidence 0.16 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0 Pain Relevance 0
Monocytes from labouring women showed significantly higher surface expression of CD11b (P = 0.001) and CD64 (P < 0.05) when compared with monocytes from non-labouring women.
Gene_expression (expression) of CD64 in monocytes
5) Confidence 0.16 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.09 Pain Relevance 0
Flow cytometric immunophenotyping demonstrated expression of HLA-DR+/CD64+, CD36+/CD116+, CD14+/-, cCD68+, CD33++, CD13+/-, CD4+ and non expression of CD34, CD79a, CD20, CD10 and, CD3.
Gene_expression (expression) of CD64
6) Confidence 0.10 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1544343 Disease Relevance 0.60 Pain Relevance 0
Flow cytometric immunophenotyping demonstrated expression of HLA-DR+/CD64+, CD36+/CD116+, CD14+/-, cCD68+, CD33++, CD13+/-, CD4+ and non expression of CD34, CD79a, CD20, CD10 and, CD3.
Gene_expression (expression) of CD64
7) Confidence 0.08 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1544343 Disease Relevance 0.62 Pain Relevance 0
Similarly, recombinant proteins derived from the Orf 25 and Orf 26 genes (major and minor capsid proteins) have been used in ELISA assays to detect IgG and IgM antibodies, but with a lesser degree of success [223].
Gene_expression (detect) of IgG associated with contagious ecthyma
8) Confidence 0.02 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 1.06 Pain Relevance 0
We have previously demonstrated raised levels of IgG and IgA antibody to the mycobacterial 65-kDa heat shock protein (hsp) in the sera of patients with rheumatoid arthritis (RA).
Gene_expression (levels) of IgG associated with shock and rheumatoid arthritis
9) Confidence 0.02 Published 1989 Journal Scand. J. Immunol. Section Abstract Doc Link 2685982 Disease Relevance 1.00 Pain Relevance 0.32
IgG, IgM and IgA levels are elevated universally in the human host upon EBV infection due to the general activation of B-cells [2].
Gene_expression (IgG) of IgG in B-cells associated with epstein-barr virus and infection
10) Confidence 0.01 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 1.06 Pain Relevance 0
High-titer values for IgG antibody production against the 30-kD protein antigen were observed in 11 out of 12 TBM patients.
Gene_expression (production) of IgG associated with mycobacterial infection
11) Confidence 0.01 Published 2004 Journal BMC Neurol Section Body Doc Link PMC529262 Disease Relevance 1.37 Pain Relevance 0.04
Additionally our results suggest that lymphocytes from CSF of TBM patients when challenged with 30 kD protein give a quick response by producing IgG antibodies when compared with that of PTPM and healthy volunteers.
Gene_expression (producing) of IgG in lymphocytes associated with mycobacterial infection and meningitis
12) Confidence 0.01 Published 2004 Journal BMC Neurol Section Body Doc Link PMC529262 Disease Relevance 1.24 Pain Relevance 0.03
When induced with the 30-kD protein antigen, B cells derived from CSF of TBM patients respond to IgG production within 24 h while those derived from PTPM patients do not respond.



Gene_expression (production) of IgG in B cells associated with mycobacterial infection and meningitis
13) Confidence 0.01 Published 2004 Journal BMC Neurol Section Abstract Doc Link PMC529262 Disease Relevance 1.50 Pain Relevance 0
Higher titers of IgG antibody production were observed in TBM patients compared to PTPM patients.
Gene_expression (production) of IgG associated with mycobacterial infection and meningitis
14) Confidence 0.01 Published 2004 Journal BMC Neurol Section Body Doc Link PMC529262 Disease Relevance 1.66 Pain Relevance 0
Similarly, we compared the laboratory findings for the anti-rLRP2 autoAb+ and autoAb- patients in SLE and SSc (in SLE, positivity for proteinuria; titers of anti-dsDNA autoAbs, anti-Sm autoAbs, and RF; WBC, lymphocyte, and platelet counts; serum levels of CRP, IgG, and IgM; and ESR; and, in SSc, positivity of proteinuria; titers of anti-nuclear antibodies, anti-Scl-70 autoAbs, and RF; WBC, lymphocyte, and platelet counts; serum levels of CRP, IgG, and IgM; and ESR).
Gene_expression (levels) of IgG in platelet associated with proteinuria, systemic sclerosis and systemic lupus erythematosus
15) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.33 Pain Relevance 0.14
Similarly, we compared the laboratory findings for the anti-rLRP2 autoAb+ and autoAb- patients in SLE and SSc (in SLE, positivity for proteinuria; titers of anti-dsDNA autoAbs, anti-Sm autoAbs, and RF; WBC, lymphocyte, and platelet counts; serum levels of CRP, IgG, and IgM; and ESR; and, in SSc, positivity of proteinuria; titers of anti-nuclear antibodies, anti-Scl-70 autoAbs, and RF; WBC, lymphocyte, and platelet counts; serum levels of CRP, IgG, and IgM; and ESR).
Gene_expression (levels) of IgG in platelet associated with proteinuria, systemic sclerosis and systemic lupus erythematosus
16) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.28 Pain Relevance 0.18
The peripheral lymphocyte counts, white blood cell (WBC) counts, platelet counts, rheumatoid factors (RFs), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum levels of IgG and IgM did not differ between the two groups (data not shown).
Gene_expression (levels) of IgG in white blood cell
17) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.09 Pain Relevance 0.19
receptor and human IgG, was subsequently introduced to Japan in March of 2005.
Gene_expression (introduced) of IgG
18) Confidence 0.01 Published 2006 Journal Mod Rheumatol Section Abstract Doc Link PMC2779400 Disease Relevance 0.89 Pain Relevance 0.39
Similarly, we compared the laboratory findings for the anti-rLRP2 autoAb+ and autoAb- patients in SLE and SSc (in SLE, positivity for proteinuria; titers of anti-dsDNA autoAbs, anti-Sm autoAbs, and RF; WBC, lymphocyte, and platelet counts; serum levels of CRP, IgG, and IgM; and ESR; and, in SSc, positivity of proteinuria; titers of anti-nuclear antibodies, anti-Scl-70 autoAbs, and RF; WBC, lymphocyte, and platelet counts; serum levels of CRP, IgG, and IgM; and ESR).
Gene_expression (levels) of IgG in lymphocyte associated with proteinuria, systemic sclerosis and systemic lupus erythematosus
19) Confidence 0.00 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.28 Pain Relevance 0.18
Similarly, we compared the laboratory findings for the anti-rLRP2 autoAb+ and autoAb- patients in SLE and SSc (in SLE, positivity for proteinuria; titers of anti-dsDNA autoAbs, anti-Sm autoAbs, and RF; WBC, lymphocyte, and platelet counts; serum levels of CRP, IgG, and IgM; and ESR; and, in SSc, positivity of proteinuria; titers of anti-nuclear antibodies, anti-Scl-70 autoAbs, and RF; WBC, lymphocyte, and platelet counts; serum levels of CRP, IgG, and IgM; and ESR).
Gene_expression (levels) of IgG in WBC associated with proteinuria, systemic sclerosis and systemic lupus erythematosus
20) Confidence 0.00 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 1.33 Pain Relevance 0.14

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