INT278783

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.32
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HOXA9) cytoplasm (HOXA9)
Anatomy Link Frequency
myeloid cells 2
stem cell 2
hematopoietic cell 2
HOXA9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 54.88 Quite High
cINOD 18 5.00 Very Low Very Low Very Low
aspirin 15 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 48 99.78 Very High Very High Very High
Myeloid Leukemia 36 99.12 Very High Very High Very High
Coronary Artery Disease 66 96.40 Very High Very High Very High
Cancer 44 90.40 High High
Apoptosis 5 59.56 Quite High
Cytomegalovirus Infection 18 32.08 Quite Low
Chronic Lymphoid Leukemia 12 6.88 Low Low
Hematologic Neoplasms 12 5.32 Low Low
Rheumatoid Arthritis 19 5.00 Very Low Very Low Very Low
Atherosclerosis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While wild-type HOXA9 is overexpressed in a subset of human AML [58], [59], [60], [61], its effects on primary human hematopoietic cell differentiation and proliferation have not been previously reported, and its contribution to human myeloid leukemogenesis is not clear.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HOXA9 in hematopoietic cell associated with myeloid leukemia
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.10 Pain Relevance 0
The two moieties of NUP98-HOXA9 act synergistically to induce proliferation of primary human CD34+ cells
Positive_regulation (induce) of Gene_expression (act) of HOXA9
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0.03
Some of these genes are also dysregulated by HOXA9 and/or HOXA9?
Positive_regulation (by) of Gene_expression (/) of HOXA9
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
For example, HOXA9 expression clearly decreased the numbers of mature myeloid cells and increased the numbers of less mature myeloid cells as judged by morphologic examination of Giemsa-stained Cytospin smears (Fig. 8 and Table 1).
Positive_regulation (increased) of Gene_expression (expression) of HOXA9 in myeloid cells
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.06 Pain Relevance 0
Wild-type HOXA9 overexpression is leukemogenic in mice [12].
Positive_regulation (overexpression) of Gene_expression (overexpression) of HOXA9
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.34 Pain Relevance 0
For example, in mice, the leukemia induced by NUP98-HOXA9 is preceded by a myeloproliferative phase whereas leukemia caused by overexpression of wild-type HOXA9 is not preceded by myeloproliferation [12]; and the in vitro effects of NUP98-HOXA9 on the differentiation and proliferation of mouse hematopoietic precursors are more profound than those of HOXA9 [13].
Positive_regulation (overexpression) of Gene_expression (overexpression) of HOXA9 associated with leukemia
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.26 Pain Relevance 0
Significantly, all but 1 of the measurable HOX genes, essential for stem cell self renewal and pluripotency were expressed at significantly higher levels in CD34+ cells with HOXA5 and HOXA9 being most strongly overexpressed (Table 4).


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HOXA9 in stem cell
7) Confidence 0.32 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.57 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox