INT278787

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HOXA9) cytoplasm (HOXA9)
HOXA9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 24.72 Low Low
cINOD 15 5.00 Very Low Very Low Very Low
aspirin 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 40 48.20 Quite Low
Cancer 35 5.00 Very Low Very Low Very Low
Myeloid Leukemia 30 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 15 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 10 5.00 Very Low Very Low Very Low
Hematologic Neoplasms 10 5.00 Very Low Very Low Very Low
Chronic Lymphoid Leukemia 10 5.00 Very Low Very Low Very Low
Repression 5 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that the effects of NUP98-HOXA9 on gene transcription and cell transformation are mediated by at least two distinct mechanisms: one that involves promoter binding through the homeodomain with direct transcriptional activation, and another that depends predominantly on the NUP98 moiety and does not involve direct DNA binding.



Positive_regulation (mediated) of HOXA9
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
The total number of cells per plate was increased in the NUP98-HOXA9 and the NUP98-HOXA9/N51S samples but not in the HOXA9 and HOXA9?
Positive_regulation (increased) of HOXA9
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
The fact that the isolated HOXA9 moiety (HOXA9?
Positive_regulation (isolated) of HOXA9
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
The fact that the isolated HOXA9 moiety (HOXA9?
Positive_regulation (isolated) of HOXA9 moiety
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Primitive cells were markedly increased in the NUP98-HOXA9 samples and mildly increased in the HOXA9 samples.
Positive_regulation (increased) of HOXA9
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0

General Comments

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