INT278788

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.16
Pain Relevance 0

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plasma membrane (OR51S1) signal transducer activity (OR51S1)
OR51S1 (Homo sapiens)
OR51S1 - N51S (6)
Pain Link Frequency Relevance Heat
cINOD 18 5.00 Very Low Very Low Very Low
aspirin 12 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 18 99.54 Very High Very High Very High
Cancer 42 41.68 Quite Low
Myeloid Leukemia 36 41.32 Quite Low
Leukemia 48 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 12 5.00 Very Low Very Low Very Low
Hematologic Neoplasms 12 5.00 Very Low Very Low Very Low
Chronic Lymphoid Leukemia 12 5.00 Very Low Very Low Very Low
Repression 6 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells were transfected by electroporation using a Bio-Rad GenePulser with 10 µg pGL4.11 vector or pGL4.11 driven by the indicated promoters and 20 µg of either empty pTracer-CMV/Bsd vector, or vector expressing HA-tagged NUP98-HOXA9 or NUP98-HOXA9/N51S.
Gene_expression (expressing) of N51S (N51S) associated with cytomegalovirus infection
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.10 Pain Relevance 0
To determine the relative contributions of the NUP98 and HOXA9 moieties to disruption of hematopoietic differentiation of primary human CD34+ cells by NUP98-HOXA9, retroviral vectors were prepared that express NUP98-HOXA9, wild-type HOXA9, NUP98-HOXA9/N51S, and a mutant of NUP98-HOXA9 that lacks the NUP98 moiety (HOXA9?
Gene_expression (express) of N51S (N51S)
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
The expression level of CD235a was decreased in cells expressing NUP98-HOXA9 and NUP98-HOXA9/N51S, indicating disrupted erythroid differentiation.
Gene_expression (expressing) of N51S (N51S)
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Cells expressing NUP98-HOXA9/N51S gave rise to a similar macroscopic appearance but with more fully hemoglobinized erythroid colonies (Fig. 7).
Gene_expression (expressing) of N51S (N51S)
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
On the other hand, cells expressing NUP98-HOXA9/N51S did not show morphologic evidence of erythroid immaturity in Giemsa-stained preparations (Fig. 8 and Table 1); yet a clear block in erythroid differentiation was observed by flow cytometry as evidenced by decreased expression of CD235a (Fig. 9A).
Gene_expression (expressing) of N51S (N51S)
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.06 Pain Relevance 0
Primary human CD34+ cells were transduced with retroviral vectors expressing NUP98-HOXA9, NUP98-HOXA9/N51S, wild-type HOXA9, and HOXA9?
Spec (partially) Gene_expression (expressing) of N51S (N51S)
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0

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