INT278790

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 0.67
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1)
DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)
Anatomy Link Frequency
brain 1
myeloid cell 1
stem cell 1
POU5F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 12 84.48 Quite High
Hippocampus 6 68.88 Quite High
cINOD 12 5.00 Very Low Very Low Very Low
tetrodotoxin 9 5.00 Very Low Very Low Very Low
Action potential 9 5.00 Very Low Very Low Very Low
Sciatic nerve 9 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
endometriosis 6 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 9 98.28 Very High Very High Very High
Leukemia 32 87.88 High High
Targeted Disruption 6 86.76 High High
Myeloid Leukemia 24 69.00 Quite High
Obesity 12 50.00 Quite Low
Injury 3 38.96 Quite Low
Carcinoma 4 11.20 Low Low
Osteoporosis 3 7.68 Low Low
Cancer 32 5.00 Very Low Very Low Very Low
Apoptosis 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated by chromatin immunoprecipitation studies that Oct4 and Sox2 bind to a few thousand regulatory sites in the ES cell genome [3], [4] and likely that many of these target genes play a modulating role in ES cell differentiation.
Oct4 Binding (bind) of
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.06 Pain Relevance 0
From these sections we performed immunohistochemical staining using a primary antibody recognizing OCT-4 (OCT-4 [C-10]: sc-5279, Santa Cruz Biotechnology, California) as previously described [12].
OCT-4 Binding (recognizing) of
2) Confidence 0.36 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0
From these sections we performed immunohistochemical staining using a primary antibody recognizing OCT-4 (OCT-4 [C-10]: sc-5279, Santa Cruz Biotechnology, California) as previously described [12].
OCT-4 Binding (recognizing) of
3) Confidence 0.36 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0
Exogenic Oct4 induced improved regeneration activity in brain trauma with high therapeutic modality
Oct4 Binding (Exogenic) of in brain associated with brain injury
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.19 Pain Relevance 0.07
Recent studies have shown Oct4 to be associated with the undifferentiated pluripotent state of stem cell populations derived from various adult tissues.
Oct4 Binding (associated) of in stem cell
5) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.09 Pain Relevance 0.03
Disruption of the differentiation of primary human CD34+ cells by NUP98-HOXA9 does not require homeodomain-DNA binding
homeodomain-DNA Binding (binding) of
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
To determine the role of homeodomain-DNA binding in the regulation of transcription by NUP98-HOXA9, luciferase reporter assays were carried out using the K562 human myeloid cell line.
homeodomain-DNA Binding (binding) of in myeloid cell
7) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
It is not known whether these effects are dependent on homeodomain-DNA binding.
homeodomain-DNA Binding (binding) of
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.34 Pain Relevance 0
To determine whether this transactivation is dependent on homeodomain-DNA binding, the N51S mutation was introduced into the homeodomain of NUP98-HOXA9 (Fig. 2A).
homeodomain-DNA Binding (binding) of
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0

General Comments

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