INT278794

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PLN) protein complex (PLN)
PLN (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 32 5.00 Very Low Very Low Very Low
Cancer 28 5.00 Very Low Very Low Very Low
Myeloid Leukemia 24 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 12 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 8 5.00 Very Low Very Low Very Low
Hematologic Neoplasms 8 5.00 Very Low Very Low Very Low
Chronic Lymphoid Leukemia 8 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore it is unlikely to represent direct specific binding of the homeodomain to the promoter, but it could represent a very weak indirect interaction between NUP98-HOXA9 and the PLN promoter that is difficult to detect by our ChIP assays.
PLN Binding (interaction) of
1) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Neither NUP98-HOXA9 nor NUP98-HOXA9/N51S showed significant binding to the segment of the PLN promoter that is transactivated by NUP98-HOXA9 (Fig. 5B).
PLN Binding (binding) of
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Taken together, these data suggest that NUP98-HOXA9 modulates transcription by at least two mechanisms: one, exemplified by the KBTBD10 promoter, involves direct binding to the promoter through the homeodomain; while the other, exemplified by the PLN promoter, does not involve DNA binding.


PLN Binding (binding) of
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Therefore it is unlikely to represent direct specific binding of the homeodomain to the promoter, but it could represent a very weak indirect interaction between NUP98-HOXA9 and the PLN promoter that is difficult to detect by our ChIP assays.
PLN Binding (binding) of
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0

General Comments

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