INT27880

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Context Info
Confidence 0.65
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 18.16
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPD1) cytosol (HSPD1) mitochondrion (HSPD1)
extracellular space (HSPD1) cell death (HSPD1) ATPase activity (HSPD1)
Anatomy Link Frequency
joint 2
plaque 1
endothelium 1
foam cell 1
T-cell 1
HSPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 202 99.66 Very High Very High Very High
rheumatoid arthritis 47 95.76 Very High Very High Very High
Angina 23 89.88 High High
cytokine 53 84.56 Quite High
Pain 2 84.12 Quite High
Osteoarthritis 3 80.60 Quite High
Arthritis 8 76.08 Quite High
Crohn's disease 50 72.32 Quite High
metalloproteinase 14 71.44 Quite High
spinal inflammation 1 71.44 Quite High
Disease Link Frequency Relevance Heat
Shock 185 100.00 Very High Very High Very High
Ovarian Cancer 11 100.00 Very High Very High Very High
Stress 84 99.72 Very High Very High Very High
Infection 138 99.70 Very High Very High Very High
INFLAMMATION 223 99.66 Very High Very High Very High
Disease 171 99.52 Very High Very High Very High
Atherosclerosis 319 99.46 Very High Very High Very High
Acute Coronary Syndrome 38 99.28 Very High Very High Very High
Chlamydia Infection 88 99.18 Very High Very High Very High
Systemic Lupus Erythematosus 148 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both cHSP60 and endogenous human (h) HSP60 are upregulated under stress conditions in intimal cells and serve as a target for cross-reactive cytotoxic HSP-serum-antibodies.
Positive_regulation (upregulated) of HSP60 associated with stress
1) Confidence 0.65 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.96 Pain Relevance 0.06
Both cHSP60 and endogenous human (h) HSP60 are upregulated under stress conditions in intimal cells and serve as a target for cross-reactive cytotoxic HSP-serum-antibodies.
Positive_regulation (upregulated) of cHSP60 associated with stress
2) Confidence 0.57 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.97 Pain Relevance 0.06
Shear stress, for example, has been identified as an inducer of HSP60 in endothelial cells [10] and it is conceivable that shear stress might have a role in HSP60 expression in the synovial lining and endothelium.
Positive_regulation (inducer) of HSP60 in endothelium associated with stress
3) Confidence 0.50 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.27 Pain Relevance 0.32
Therefore, for the therapy of small intestinal mucosal lesion, HSP60-induction therapy could be a new therapeutic strategy.


Positive_regulation (induction) of HSP60
4) Confidence 0.48 Published 2010 Journal Life Sci. Section Body Doc Link 20159025 Disease Relevance 0 Pain Relevance 0
Levels of specific serum Ab against hsp60 were significantly elevated in patients with ACS when compared to clinically healthy subjects.
Positive_regulation (elevated) of hsp60 associated with acute coronary syndrome
5) Confidence 0.47 Published 2002 Journal Cardiovasc. Pathol. Section Abstract Doc Link 12140130 Disease Relevance 0.95 Pain Relevance 0.08
Immune response to HSP60/65-derived peptide in inflamed colonic mucosa are skewed toward an inflammatory rather than a regulatory phenotype
Positive_regulation (response) of HSP60/65-derived associated with inflammation
6) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.27 Pain Relevance 0.12
We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP.


Positive_regulation (circulating) of HSP60 associated with periodontitis and inflammation
7) Confidence 0.42 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2065903 Disease Relevance 0.51 Pain Relevance 0.09
They studied the joint effect of chronic Chlamydia pneumoniae (CP) infection, persistently elevated human heat-shock protein 60 (h-hsp60) antibodies and C-reactive protein (CRP) on coronary risk.
Positive_regulation (elevated) of heat-shock protein 60 in joint associated with shock, chlamydia infection and infection
8) Confidence 0.37 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1458355 Disease Relevance 1.15 Pain Relevance 0.05
These findings suggest that elevated IgG antibody levels to the mycobacterial hsp65 shows some disease specificity, and further studies with the human homologue and at the T-cell level are required.
Positive_regulation (elevated) of hsp65 in T-cell associated with disease
9) Confidence 0.31 Published 1989 Journal Scand. J. Immunol. Section Abstract Doc Link 2685982 Disease Relevance 1.84 Pain Relevance 0.47
Two independent groups have shown that an elevated anti-human hsp60 antibody level is a risk factor for primary coronary atherosclerosis, especially when it is present with Chlamydia pneumoniae infection [11,12].
Positive_regulation (elevated) of hsp60 associated with coronary artery disease, chlamydia infection and infection
10) Confidence 0.29 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1458355 Disease Relevance 2.01 Pain Relevance 0.06
Instead, a 7-fold risk emerged when an elevated level of IgA antibodies to CP in baseline serum was accompanied by factors related to auto-immunity and inflammation, such as elevated levels of h-hsp60 IgA antibodies and CRP.
Positive_regulation (levels) of hsp60 associated with inflammation
11) Confidence 0.29 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1458355 Disease Relevance 0.76 Pain Relevance 0.11
They studied the joint effect of chronic Chlamydia pneumoniae (CP) infection, persistently elevated human heat-shock protein 60 (h-hsp60) antibodies and C-reactive protein (CRP) on coronary risk.
Positive_regulation (elevated) of hsp60 in joint associated with shock, chlamydia infection and infection
12) Confidence 0.29 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1458355 Disease Relevance 1.15 Pain Relevance 0.05
Pathogen burden correlated highly significant (p<0.01) with the expression of hHSP60 (r=0.44).Our data demonstrate the impact of intimal pathogen burden in plaque instability, and suggest the presence of (auto-)immunoreactions against upregulated hHSP60 as an important pathomechanism that may contribute to acute coronary syndromes.
Positive_regulation (upregulated) of hHSP60 in plaque associated with acute coronary syndrome
13) Confidence 0.17 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12955411 Disease Relevance 1.53 Pain Relevance 0.38
products of the inflammatory process such as endogenous HSP60 and LDL oxidation
Positive_regulation (endogenous) of HSP60 associated with inflammation
14) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.35 Pain Relevance 0.12
shown to induce macrophage foam cell formation and chlamydial HSP60 is known to
Positive_regulation (induce) of HSP60 in foam cell
15) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.15 Pain Relevance 0.19
Analyzed by peptide fragment matching and MS/MS, cisplatin caused notably increase expressions of some proteins in ovarian cancer, including tropomyosin family, actin family, triosephosphate isomerase family, and Hsp60, while expressions of some proteins in the enolase family decreased.
Positive_regulation (increase) of Hsp60 associated with ovarian cancer
16) Confidence 0.08 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.17 Pain Relevance 0
Furthermore, patients with sonographic evidence of carotid atherosclerotic lesions had significantly elevated levels of anti-HSP65 when compared to controls [22, 28].


Positive_regulation (elevated) of anti-HSP65 associated with atherosclerosis
17) Confidence 0.07 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2779351 Disease Relevance 0.96 Pain Relevance 0.04
Patients with high levels of anti-HSP65 were found to be at increased risk of subsequent cardiovascular events and cardiovascular mortality [26, 27].
Positive_regulation (levels) of anti-HSP65
18) Confidence 0.07 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2779351 Disease Relevance 1.16 Pain Relevance 0.03

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