INT27881

Context Info Confidence 0.31 First Reported 1989 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 12 Disease Relevance 9.20 Pain Relevance 1.78

unfolded protein binding (HSPD1) cytosol (HSPD1) mitochondrion (HSPD1) extracellular space (HSPD1) cell death (HSPD1) ATPase activity (HSPD1)

Anatomy Link Frequency foam cell 1 T cells 1 HSPD1 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 36 99.36 Inflammation 170 98.16 Infliximab 4 94.72 Crohn's disease 1 91.72 spinal inflammation 1 90.84 cytokine 42 88.80 metalloproteinase 12 87.92 Inflammatory mediators 5 86.64 methotrexate 2 72.16 Inflammatory response 30 70.20

Disease Link Frequency Relevance Heat Periodontitis 38 100.00 Mycobacterial Infection 5 99.50 Rheumatoid Arthritis 36 99.36 INFLAMMATION 205 98.16 Atherosclerosis 201 97.28 Disease 214 96.32 Nicotine Addiction 11 93.84 Pneumonia 3 93.16 Infection 41 92.52 Autoimmune Disease 12 92.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, there was a weaker association between periodontitis and HSP60 levels (Figure 1).

HSP60 Binding (association) of associated with periodontitis

1) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.75 Pain Relevance 0.03

It is interesting to speculate whether individuals with low levels of HSP60 have their local anti-bacterial defences compromised by the action of this protein?

HSP60 Binding (individuals) of

2) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.85 Pain Relevance 0.26

Similarly, only RA and TB sera show increased IgG binding to the mycobacterial hsp65, and we have shown previously that the titre is greater in RA.

hsp65 Binding (binding) of associated with mycobacterial infection and rheumatoid arthritis

3) Confidence 0.22 Published 1989 Journal Scand. J. Immunol. Section Abstract Doc Link 2685982 Disease Relevance 1.92 Pain Relevance 0.55

Furthermore, both receptors also bind to the endogenous 60 kDa HSP (HSP60), leading to cell activation [10,11].

HSP60 Binding (bind) of

4) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.41 Pain Relevance 0.16

(R&D; Minneapolis, MN, USA), polymyxin B and LPS Escherichia coli O111: B4 (Calbiochem; La Jolla, CA, USA), low endotoxin recombinant human HSP60 (Stressgen; Victoria, Canada), and IgG1?

HSP60 Binding (recombinant) of

5) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.35 Pain Relevance 0.24

against these viral proteins can bind to human HSP60 expressed on stressed

HSP60 Binding (bind) of

6) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.05 Pain Relevance 0.10

autoantibodies such as those binding to endogenous human HSP60 and oxidised LDL

HSP60 Binding (binding) of

7) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.48 Pain Relevance 0.25

shown to induce macrophage foam cell formation and chlamydial HSP60 is known to

HSP60 Binding (formation) of in foam cell

8) Confidence 0.06 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 1.13 Pain Relevance 0.19

None reacted with hHSP60.

hHSP60 Binding (reacted) of

9) Confidence 0.01 Published 2004 Journal Circulation Section Body Doc Link 14993140 Disease Relevance 0.05 Pain Relevance 0

Incubation of the cells with anti-MHC class II and anti-CD4 antibodies but not anti-class I antibodies blocked antigen presentation, confirming recognition of the hHSP60 to be via the MHC class II pathway.

hHSP60 Binding (recognition) of

10) Confidence 0.01 Published 2004 Journal Circulation Section Body Doc Link 14993140 Disease Relevance 0.06 Pain Relevance 0

CONCLUSIONS: We have shown that hHSP60 is an antigen recognized by CD4+CD28null T cells of ACS patients.

hHSP60 Binding (recognized) of in T cells

11) Confidence 0.01 Published 2004 Journal Circulation Section Body Doc Link 14993140 Disease Relevance 0.05 Pain Relevance 0

CD4+CD28null cells from 12 of 21 patients with ACS reacted with hHSP60.

hHSP60 Binding (reacted) of

12) Confidence 0.01 Published 2004 Journal Circulation Section Body Doc Link 14993140 Disease Relevance 0.07 Pain Relevance 0

General Comments

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