INT27882

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 52
Total Number 52
Disease Relevance 36.51
Pain Relevance 9.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) response to stress (HSP90B2P)
Anatomy Link Frequency
cornea 4
lymphocytes 3
lens 2
corneal epithelium 2
macrophages 1
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
Antinociceptive 10 99.92 Very High Very High Very High
dexamethasone 2 99.56 Very High Very High Very High
cINOD 17 99.50 Very High Very High Very High
cytokine 102 99.40 Very High Very High Very High
rheumatoid arthritis 84 99.36 Very High Very High Very High
ischemia 15 99.08 Very High Very High Very High
Inflammation 208 98.88 Very High Very High Very High
tolerance 182 98.12 Very High Very High Very High
Crohn's disease 107 98.00 Very High Very High Very High
Analgesic 7 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 582 100.00 Very High Very High Very High
Shock 385 100.00 Very High Very High Very High
Targeted Disruption 255 100.00 Very High Very High Very High
Ataxia 7 100.00 Very High Very High Very High
Cataract 340 99.92 Very High Very High Very High
Manic Depressive Disorder 3 99.80 Very High Very High Very High
Skin Cancer 101 99.46 Very High Very High Very High
Fever 323 99.40 Very High Very High Very High
Rheumatoid Arthritis 84 99.36 Very High Very High Very High
Corneal Opacity 85 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a central finding, the expression of both HSP homologues was significantly (each p<0.001) higher in ACS lesions compared to SA lesions (cHSP60: 6.2 vs 1.0%, and hHSP60: 7.2 vs 0.7%).
Gene_expression (expression) of HSP
1) Confidence 0.75 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.97 Pain Relevance 0.07
Heat shock protein (HSP) synthesis is induced by hyperthermia and other types of stress in mammalian cells in vitro and in vivo.
Gene_expression (synthesis) of HSP associated with stress, shock and fever
2) Confidence 0.75 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7671259 Disease Relevance 0.43 Pain Relevance 0.11
Recently, SQDB was found to induce intestinal microflora which, in turn, altered HSP gene expression [30].
Gene_expression (expression) of HSP
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825258 Disease Relevance 0.78 Pain Relevance 0.28
In contrast, the use of mycobacterial and E. coli hsp70 preparations as control bacterial hsp gene products has shown that RA patients do not differ from TB or SLE patients in their antibody binding to these proteins.
Gene_expression (products) of hsp associated with mycobacterial infection, rheumatoid arthritis and systemic lupus erythematosus
4) Confidence 0.65 Published 1989 Journal Scand. J. Immunol. Section Abstract Doc Link 2685982 Disease Relevance 1.90 Pain Relevance 0.53
Further evidence for a possible direct antioxidant effect of allopurinol comes from models of experimental colitis where tungsten (a potent XO inhibitor) failed to improve symptoms whereas allopurinol did.69 Augustin et al suggested that this direct effect was only seen at higher doses.70 This was also seen in mice paracetamol toxicity models where lower doses (sufficient to block XO activity) of allopurinol failed to show antioxidant protection but higher doses did.71 There have been other non-XO effects of allopurinol suggested such as copper chelation, preventing LDL oxidation as described above,72 inhibition of heat shock protein (hsp) expression73 and calcium sensitization (below).
Gene_expression (expression73) of hsp associated with colitis, toxicity, paracetamol and shock
5) Confidence 0.65 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.60 Pain Relevance 0.14
We have previously demonstrated raised levels of IgG and IgA antibody to the mycobacterial 65-kDa heat shock protein (hsp) in the sera of patients with rheumatoid arthritis (RA).
Gene_expression (levels) of hsp associated with shock and rheumatoid arthritis
6) Confidence 0.58 Published 1989 Journal Scand. J. Immunol. Section Abstract Doc Link 2685982 Disease Relevance 1.06 Pain Relevance 0.34
Furthermore, during HSP, antinociceptive responsiveness to i.t.
Gene_expression (during) of HSP associated with antinociceptive
7) Confidence 0.51 Published 1996 Journal Pain Section Abstract Doc Link 8783328 Disease Relevance 0 Pain Relevance 1.59
Furthermore, during HSP, antinociceptive responsiveness to i.t.
Gene_expression (during) of HSP associated with antinociceptive
8) Confidence 0.43 Published 1996 Journal Pain Section Abstract Doc Link 8867260 Disease Relevance 0.05 Pain Relevance 1.59
The novel gene expression connection between HSP and Bipolar disorder indicates that they may share some common underlying molecular mechanism.
Gene_expression (expression) of HSP associated with manic depressive disorder and ataxia
9) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715883 Disease Relevance 2.27 Pain Relevance 0
In addition, inflamed biopsies showed an abundance of HSP60 expression, including in CD4 positive cells, confirming visually a direct link between immunologically relevant cells and expression of HSP in the presence of chronic inflammation.
Gene_expression (expression) of HSP associated with inflammation
10) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.90 Pain Relevance 0.47
P450 2C9 overexpression induced endoplasmic reticulum (ER) stress and regulated genes implicated in the unfolded protein response (UPR) as heat shock protein (HSP) (we studied particurlarly HSPA5 and HSPB1) and in the endoplasmic reticulum associated degradation (ERAD) system as Sec61 and ubiquitin and proteasome pathways.
Gene_expression (overexpression) of HSP in reticulum associated with stress and shock
11) Confidence 0.29 Published 2009 Journal Chem. Res. Toxicol. Section Abstract Doc Link 19445531 Disease Relevance 0.53 Pain Relevance 0.09
Furthermore, addition of an antibody against TRX induced cell death in keratinocytes, probably due to enhanced signaling of MSH, as it has been shown that MSH suppresses heat shock protein (hsp) 70 expression in differentiated keratinocytes, which express high levels of MC1-R and decreases their survival rate during oxidative stress.
Gene_expression (expression) of hsp in keratinocytes associated with stress, shock and death
12) Confidence 0.28 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.29 Pain Relevance 0.23
Proinflammatory reactivity to HSP-derived peptides is found in inflamed but not in normal mucosa in CD patients, UC patients or healthy patients
Gene_expression (peptides) of HSP-derived associated with inflammatory bowel disease and crohn's disease
13) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.91 Pain Relevance 0.31
Since many pharmaceutical companies are developing cytokine synthesis inhibitors as potential anti-inflammatory drugs, one aim of this article is to emphasize that understanding the molecular mechanism(s) that lead to increased HSP expression and decreased cytokine biosynthesis may assist in achieving this goal.
Gene_expression (expression) of HSP associated with inflammation, cinod and cytokine
14) Confidence 0.21 Published 1994 Journal Experientia Section Abstract Doc Link 7988664 Disease Relevance 0.55 Pain Relevance 0.45
Other studies suggest that various anti-inflammatory drugs, including acetylsalicyclic acid, auranofin and dexamethasone, can also facilitate HSP expression in macrophages.
Gene_expression (expression) of HSP in macrophages associated with inflammation, cinod and dexamethasone
15) Confidence 0.21 Published 1994 Journal Experientia Section Abstract Doc Link 7988664 Disease Relevance 0.65 Pain Relevance 0.46
Overlapping primer amplification strategy to span entire cagPAI worked very well with our hsp-Amerind isolates (Figure 3A) where all the constituent genes of the PAI were successfully amplified.
Gene_expression (worked) of hsp
16) Confidence 0.20 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553449 Disease Relevance 0.51 Pain Relevance 0
Hsp expression patterns were elucidated with Western blot and immunohistochemical staining.
Gene_expression (expression) of Hsp
17) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2816848 Disease Relevance 0.67 Pain Relevance 0
In Group N, Hsp 70 was expressed in keratocytes of the limbus and in the entire endothelium, but was not expressed in the central cornea.
Gene_expression (expressed) of Hsp in cornea
18) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.05 Pain Relevance 0
Our cell culture study showed that maximal expression of Hsp 70 occurred 6 hr after an inductive event, so recovery was provided for 6 hr.


Gene_expression (expression) of Hsp
19) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.06 Pain Relevance 0.05
We confirmed the increased expression of Hsp in the cornea and lens after heating and cooling (Fig. 4).
Gene_expression (expression) of Hsp in lens
20) Confidence 0.09 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.44 Pain Relevance 0

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