INT27892

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Context Info
Confidence 0.58
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.26
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
muscle 6
skeletal muscle 2
small intestine 2
left coronary artery 2
ck (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
Pain 13 100.00 Very High Very High Very High
Acupuncture 5 98.86 Very High Very High Very High
ischemia 19 98.08 Very High Very High Very High
Analgesic 6 98.04 Very High Very High Very High
adenocard 10 97.68 Very High Very High Very High
Pain score 3 97.28 Very High Very High Very High
alcohol 2 96.08 Very High Very High Very High
cocaine 1 95.48 Very High Very High Very High
halothane 4 95.04 Very High Very High Very High
Cannabinoid 1 94.32 High High
Disease Term Frequency Confidence Heat
Injury 36 100.00 Very High Very High Very High
Pain 11 100.00 Very High Very High Very High
Myalgia 10 99.72 Very High Very High Very High
Cv General 4 Under Development 4 98.56 Very High Very High Very High
Coronary Artery Disease 23 98.08 Very High Very High Very High
Cv Unclassified Under Development 11 97.96 Very High Very High Very High
Muscular Dystrophy 1 94.40 High High
No-reflow Phenomenon 2 91.52 High High
Rhabdomyolysis 22 90.16 High High
Myocardial Infarction 32 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the predicted CK release and maximal QRS-vector change for a given initial ST-vector magnitude was significantly reduced by timolol.
Negative_regulation (reduced) of Localization (release) of CK
1) Confidence 0.58 Published 1984 Journal Am. J. Cardiol. Section Abstract Doc Link 6391134 Disease Relevance 0.25 Pain Relevance 0.23
Furthermore, QRS evolution time and CK release time were significantly reduced after intravenous timolol, as were the need for analgesics and the pain scores.
Negative_regulation (reduced) of Localization (release) of CK associated with pain score and analgesic
2) Confidence 0.52 Published 1986 Journal Am. J. Cardiol. Section Abstract Doc Link 2871742 Disease Relevance 0.33 Pain Relevance 0.24
L-carnitine significantly reduced pain, tenderness and CK release after the effort with respect to placebo.
Negative_regulation (reduced) of Localization (release) of CK associated with pain
3) Confidence 0.51 Published 1996 Journal Int J Sports Med Section Abstract Doc Link 8858401 Disease Relevance 0.70 Pain Relevance 0.61
Timolol reduced myocardial ischemia and infarct size as measured by an accelerated reduction in ST-vector magnitude, a significant reduction in maximal cumulative CK release (29.5%) and significantly smaller changes in QRS-vector parameters (20 to 25%).
Negative_regulation (reduction) of Localization (release) of CK associated with coronary artery disease and ischemia
4) Confidence 0.51 Published 1984 Journal Am. J. Cardiol. Section Abstract Doc Link 6391134 Disease Relevance 0.26 Pain Relevance 0.20
The predicted maximal QRS vector change and cumulative CK release for any given initial ST-vector magnitude was significantly reduced in the timolol-treated patients.
Negative_regulation (reduced) of Localization (release) of CK
5) Confidence 0.45 Published 1986 Journal Am. J. Cardiol. Section Abstract Doc Link 2871742 Disease Relevance 0.25 Pain Relevance 0.22
Preconditioning induced by a brief period of 10-min small intestine ischaemia significantly reduced infarct size (6.5+/-1.9%, P<0.01 vs. the control non-preconditioned group) and decreased CK release (3092+/-236 and 1094+/-117 U/l for myocardial ischaemia-reperfusion and preconditioning plus myocardial ischemia-reperfusion, respectively, P<0.01), and the protection was partly abolished by pretreatment with capsaicin (50 mg/kg, s.c.) 4 days before the experiments.
Negative_regulation (decreased) of Localization (release) of CK in small intestine associated with qutenza, cv general 4 under development, ischemia and cv unclassified under development
6) Confidence 0.41 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10208312 Disease Relevance 0.64 Pain Relevance 0.39
CONCLUSION: The data indicate that therapeutic doses of naproxen do not prevent CK release into the plasma but decrease the perception of muscle soreness and positively influence quadriceps peak torque.


Negative_regulation (prevent) of Localization (release) of CK in muscle
7) Confidence 0.38 Published 1998 Journal Clin J Sport Med Section Body Doc Link 9641434 Disease Relevance 0 Pain Relevance 0
The timolol group had reduced myocardial ischemia and infarct size as measured by an accelerated reduction of ST-vector magnitude, a significant reduction of creatine kinase (CK) release and significantly smaller changes in QRS vector variables.
Negative_regulation (reduction) of Localization (release) of CK associated with coronary artery disease and ischemia
8) Confidence 0.38 Published 1986 Journal Am. J. Cardiol. Section Abstract Doc Link 2871742 Disease Relevance 0.26 Pain Relevance 0.19
Sudden interruption of motor activity induced by general anaesthesia seems to be the most important factor in reducing the release of CK from muscle.
Negative_regulation (reducing) of Localization (release) of CK in muscle
9) Confidence 0.34 Published 1989 Journal Minerva Anestesiol Section Abstract Doc Link 2779807 Disease Relevance 0.33 Pain Relevance 0.34
CK release was decreased by lidocaine.
Negative_regulation (decreased) of Localization (release) of CK
10) Confidence 0.30 Published 2010 Journal Equine Vet. J. Section Body Doc Link 20121914 Disease Relevance 0 Pain Relevance 0
These results suggest that acupuncture is effective in decreasing muscle soreness but does not prevent CK release from muscle.
Negative_regulation (prevent) of Localization (release) of CK in muscle associated with acupuncture and myalgia
11) Confidence 0.20 Published 1999 Journal Am. J. Chin. Med. Section Abstract Doc Link 10592838 Disease Relevance 0.42 Pain Relevance 0.21
However, any concomitant release of CK-MM3 from skeletal muscle would decrease the clinical utility of MM isoforms in detecting myocardial damage.
Negative_regulation (decrease) of Localization (release) of CK in skeletal muscle
12) Confidence 0.17 Published 1989 Journal Clin. Lab. Med. Section Abstract Doc Link 2686906 Disease Relevance 0.25 Pain Relevance 0
Creatine kinase (CK) on admission was 6,284 U/L, with CK-MB of 8.4 ?
Negative_regulation (admission) of Localization (Creatine kinase) of CK
13) Confidence 0.13 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC1824724 Disease Relevance 0.43 Pain Relevance 0.21
A small clinical trial consisting of 28 patients (16 in the control group and 12 in the adenosine group) showed that the intracoronary administration of adenosine (1 mg/min in the right coronary artery or 2 mg/min in the left coronary artery) over a 10-minute period during PCI reduced release of serum CK-MB 24 hours after PCI [48].
Negative_regulation (reduced) of Localization (release) of CK-MB in left coronary artery associated with adenocard
14) Confidence 0.11 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2780824 Disease Relevance 0.73 Pain Relevance 0.38
Atorvastatin pretreatment was associated with a significant reduction in the release of all myocardial injury indicators like myoglobin, troponin I, and CK-MB following the percutaneous procedure [5].
Negative_regulation (reduction) of Localization (release) of CK-MB associated with injury
15) Confidence 0.04 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2927584 Disease Relevance 0.41 Pain Relevance 0.04

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