INT278937

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.42
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP, IL6) extracellular region (LEP, IL6) aging (IL6)
lipid metabolic process (LEP)
Anatomy Link Frequency
cartilage 4
epithelial cells 2
LEP (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 252 99.60 Very High Very High Very High
Inflammation 32 95.60 Very High Very High Very High
Arthritis 4 94.92 High High
cytokine 20 86.16 High High
metalloproteinase 12 73.60 Quite High
Kinase C 24 63.36 Quite High
Pain 8 59.72 Quite High
cINOD 12 56.36 Quite High
Kinase C inhibitor 4 50.76 Quite High
antagonist 4 47.84 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 264 99.60 Very High Very High Very High
INFLAMMATION 36 95.60 Very High Very High Very High
Arthritis 4 94.92 High High
Obesity 60 90.80 High High
Chronic Disease 4 79.16 Quite High
Adenocarcinoma 4 72.68 Quite High
Death 4 61.44 Quite High
Pain 8 59.72 Quite High
Inflammatory Pain 4 39.84 Quite Low
Glioma 4 15.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that leptin induced the production of NO, PGE2, IL-6, and IL-8 in human osteoarthritic cartilage and that leptin-induced PGE2, IL-6, and IL-8 production was dependent on NO.
leptin Positive_regulation (induced) of Gene_expression (production) of IL-6 in cartilage associated with osteoarthritis
1) Confidence 0.32 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.87 Pain Relevance 0.29
Leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2, and production of NO, PGE2, IL-6, and IL-8.
Leptin Positive_regulation (enhanced) of Gene_expression (production) of IL-6
2) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2726438 Disease Relevance 0.80 Pain Relevance 0.28
In the present study, we show for the first time that leptin enhances IL-6 and IL-8 production in human OA cartilage (Figures 1(e), 1(f) and 2(e), 2(f)).
leptin Positive_regulation (enhances) of Gene_expression (production) of IL-6 in cartilage associated with osteoarthritis
3) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.95 Pain Relevance 0.74
Leptin has previously been shown to induce IL-6 production in human dendritic cells, human monocytes, human endometrial stromal cells (ESC), and in epithelial cells [55–57], and to stimulate IL-8 production in human endometrial stromal cells (ESCs) and in epithelial cells [56].
Leptin Positive_regulation (induce) of Gene_expression (production) of IL-6 in epithelial cells
4) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.80 Pain Relevance 0.66

General Comments

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