INT278944

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.09
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ZEB1) aging (IL1B) intracellular (ZEB1)
cell-cell signaling (IL1B) cytoplasm (ZEB1) cell proliferation (ZEB1)
Anatomy Link Frequency
chondrocyte 1
ZEB1 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 100.00 Very High Very High Very High
Osteoarthritis 63 97.96 Very High Very High Very High
antagonist 1 82.36 Quite High
Inflammation 8 79.76 Quite High
Kinase C 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Kinase C inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 100.00 Very High Very High Very High
Osteoarthritis 66 97.96 Very High Very High Very High
Targeted Disruption 1 86.24 High High
INFLAMMATION 9 79.76 Quite High
Osteophyte 2 78.48 Quite High
Death 1 75.36 Quite High
Cancer 1 57.84 Quite High
Necrosis 1 57.36 Quite High
Obesity 15 49.52 Quite Low
Glioma 1 48.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In further studies with this model, L-NIL was shown to reduce the levels of matrix metalloproteinase-1 and -3 (MMP-1 and -3) [23], to inhibit chondrocyte apoptosis [36] and to reduce the interleukin-1 converting enzyme (ICE) levels [37].
L-NIL Negative_regulation (reduce) of interleukin-1 in chondrocyte associated with metalloproteinase and apoptosis
1) Confidence 0.00 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 1.09 Pain Relevance 0.39

General Comments

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