INT278946

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.90
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, IL8) extracellular region (IL6, IL8) signal transduction (IL8)
aging (IL6) intracellular (IL8)
Anatomy Link Frequency
cartilage 4
IL6 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 252 98.60 Very High Very High Very High
Kinase C 24 93.00 High High
metalloproteinase 12 82.72 Quite High
Inflammation 32 80.04 Quite High
Kinase C inhibitor 4 77.20 Quite High
cytokine 20 59.12 Quite High
antagonist 4 56.96 Quite High
cINOD 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 264 99.18 Very High Very High Very High
Obesity 60 85.92 High High
INFLAMMATION 36 80.04 Quite High
Chronic Disease 4 74.28 Quite High
Death 4 70.56 Quite High
Apoptosis 4 11.44 Low Low
Osteophyte 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Adenocarcinoma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the fourth series of experiments, signaling mechanisms involved in the leptin-induced NO, PGE2, IL-6, and IL-8 production were studied using pharmacological inhibitors.
IL-6 Regulation (involved) of Gene_expression (production) of IL-8
1) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.32 Pain Relevance 0.16
In the present study, we found that leptin induced the production of NO, PGE2, IL-6, and IL-8 in human osteoarthritic cartilage and that leptin-induced PGE2, IL-6, and IL-8 production was dependent on NO.
IL-6 Neg (NO) Regulation (dependent) of Gene_expression (production) of IL-8 in cartilage associated with osteoarthritis
2) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.88 Pain Relevance 0.30
M) inhibited leptin-induced PGE2 production, but had no effect on NO, IL-6, or IL-8 production.
IL-6 Neg (no) Regulation (effect) of Gene_expression (production) of IL-8
3) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.20 Pain Relevance 0.17
In the present study, inhibition of leptin-induced endogenous NO production in OA cartilage with a selective iNOS inhibitor 1400 W also suppressed the effects of leptin on PGE2, IL-6, and IL-8 production.
IL-6 Regulation (effects) of Gene_expression (production) of IL-8 in cartilage associated with osteoarthritis
4) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.50 Pain Relevance 0.37

General Comments

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