INT278948

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.04
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) plasma membrane (PTGER2)
signal transducer activity (PTGER2) lipid metabolic process (LEP)
Anatomy Link Frequency
cartilage 6
OE33 2
LEP (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 252 99.84 Very High Very High Very High
Pain 8 97.36 Very High Very High Very High
cINOD 12 94.00 High High
cytokine 20 89.20 High High
Kinase C 24 86.64 High High
IPN 4 77.48 Quite High
Inflammation 32 75.76 Quite High
metalloproteinase 12 73.12 Quite High
Kinase C inhibitor 4 50.76 Quite High
antagonist 4 47.36 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 264 99.84 Very High Very High Very High
Adenocarcinoma 4 98.84 Very High Very High Very High
Pain 8 97.36 Very High Very High Very High
INFLAMMATION 36 93.08 High High
Obesity 60 90.80 High High
Chronic Disease 4 79.16 Quite High
Inflammatory Pain 4 77.48 Quite High
Death 4 60.96 Quite High
Glioma 4 52.96 Quite High
Necrosis 4 48.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that leptin induced the production of NO, PGE2, IL-6, and IL-8 in human osteoarthritic cartilage and that leptin-induced PGE2, IL-6, and IL-8 production was dependent on NO.
leptin Positive_regulation (induced) of Gene_expression (production) of PGE2 in cartilage associated with osteoarthritis
1) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.87 Pain Relevance 0.29
Previously, leptin has been shown to induce PGE2 production in OE33 Barret's esophageal adenocarcinoma (EAC) cell-line and in murine J774A.1 macrophages [39, 48].
leptin Positive_regulation (induce) of Gene_expression (production) of PGE2 in OE33 associated with adenocarcinoma
2) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 1.27 Pain Relevance 1.01
To our knowledge, we show here for the first time that leptin increases COX-2 expression and PGE2 production in human OA cartilage in the absence and in the presence of IL-1 (Figures 1(c), 1(d) and 2(c), 2(d)).
leptin Positive_regulation (increases) of Gene_expression (production) of PGE2 in cartilage associated with osteoarthritis
3) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 1.34 Pain Relevance 1.01
Those results suggest that leptin induces PGE2, IL-6, and IL-8 production in OA cartilage by an NO-dependent manner.
leptin Positive_regulation (induces) of Gene_expression (production) of PGE2 in cartilage associated with osteoarthritis
4) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.56 Pain Relevance 0.39

General Comments

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