INT278955

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (JAK3, PRKCA) cytosol (JAK3, PRKCA) nucleoplasm (PRKCA)
mitochondrion (PRKCA) small molecule metabolic process (PRKCA) endoplasmic reticulum (PRKCA)
JAK3 (Homo sapiens)
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 6 100.00 Very High Very High Very High
Osteoarthritis 63 99.00 Very High Very High Very High
Inflammation 8 38.24 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Kinase C inhibitor 1 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 66 99.00 Very High Very High Very High
Obesity 15 65.68 Quite High
INFLAMMATION 9 38.24 Quite Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Adenocarcinoma 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, JAK3 signaling seems to be involved in leptin-induced NO production, p38, and Erk1/2 MAPK pathways in leptin-induced PGE2 production, and PKC pathway in leptin-induced NO, IL-6, and IL-8 production.
JAK3 Positive_regulation (involved) of Gene_expression (pathway) of PKC associated with kinase c
1) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.65 Pain Relevance 0.37

General Comments

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