INT278961

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, LEP) extracellular region (IL6, LEP) aging (IL6)
lipid metabolic process (LEP)
Anatomy Link Frequency
cartilage 2
IL6 (Homo sapiens)
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 63 94.24 High High
metalloproteinase 3 82.72 Quite High
Inflammation 8 66.16 Quite High
antagonist 1 56.96 Quite High
Kinase C inhibitor 1 46.72 Quite Low
Kinase C 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 66 99.60 Very High Very High Very High
Obesity 15 86.76 High High
Chronic Disease 1 75.12 Quite High
Death 1 70.56 Quite High
INFLAMMATION 9 66.16 Quite High
Apoptosis 1 11.44 Low Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Adenocarcinoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that leptin induced the production of NO, PGE2, IL-6, and IL-8 in human osteoarthritic cartilage and that leptin-induced PGE2, IL-6, and IL-8 production was dependent on NO.
IL-6 Neg (NO) Regulation (dependent) of Gene_expression (production) of leptin-induced in cartilage associated with osteoarthritis
1) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.89 Pain Relevance 0.30

General Comments

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